The importance of cellular infiltrates in tissues has been investigated as a diagnostic tool, mechanism of pathogenesis, and prognostic indicator in certain human diseases. Eosinophils, in particular, have a distinct role in the development of cutaneous lesions in human autoimmune diseases. Identification of an eosinophilic infiltrate can aid the diagnosis of immunobullous disease in the early ...

IMPORTANCE Disease burden data helps guide research prioritization. OBJECTIVE To determine the extent to which grants issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) reflect disease burden, measured by disability-adjusted life years (DALYs) from Global Burden of Disease (GBD) 2010 project. DESIGN Two investigators independently assessed 15 skin co...

The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two ends of the spectrum of severe immunobullous state characterized by keratinocyte apoptosis. The present study aimed to draw attention to various epidemiological features of SJS and TEN diseases such as causative drugs, underlying diseases, duration of hospitalization, and types of treatment. The records of all patie...

INTRODUCTION Bullous pemphigoid (BP) is the most common immunobullous disorder in Western Europe, affecting mainly the elderly. Previous reports have suggested that it is rarer in the Far East. We report on the clinico-epidemiological features of BP seen at our centre. MATERIALS AND METHODS This is a 2-year retrospective study of patients seen at the National Skin Centre who were diagnosed to...

BACKGROUND Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepa...

Dermatologic disorders frequently parallel with oral involvement which dental practitioners should be familiar with. In continuation with part II, the immunofluorescence patterns in the intraepidermal pemphigus group and its variants: Pemphigus vulgaris (PV) and paraneoplastic pemphigus (PNP) are dealt in this section. Also, a brief note is added on other mucocutaneous disorders showing similar...

Orf is a rare viral zoonosis due to Parapoxvirus infection. Transmission humans occurs through contact with infected goats and sheep. It may be complicated by fever, lymphangitis, lymphadenopathy, bacterial infection, erythema multiforme. Only several cases of autoimmune bullous dermatoses have been described. Bullous pemphigoid secondary an orf was found in ten patients. Herein, we report one ...