BACKGROUND Inflammatory cytokine genes have been proposed as good candidate genes for conferring susceptibility to diabetic nephropathy. In the present study, we examined the combined effect of multiple alleles of pro inflammatory cytokine genes for determining the risk of nephropathy in type 2 diabetic patients. METHODOLOGY/PRINCIPAL FINDINGS Eight single nucleotide polymorphisms (SNPs) of p...

Kindlin-2 is a novel focal adhesion gene mediating the cell-extracellular matrix (ECM) adhesion. Tumor-associated macrophages (TAMs) play an important role in linking chronic inflammation to cancer progression. Both kindlin-2 and TAMs have been found to promote the invasion of gastric cancer cells in our previous studies. However, the correlation ...

abstract background and aim: oral cancer is one of the most common cancers of the head and neck. considering the high prevalence and mortality percentage of oral cancer and the significant advances in immunology and identification of different cytokines, the aim of the present study was to compare the concentration of il8 in saliva of patients with oral squamous cell carcinoma (oscc) and health...

In this paper, we launch a program to describe and classify modular invariant representations of infinite-dimensional Lie algebras and superalgebras. We prove a character formula for a large class of highest weight representations L(lambda) of a Kac-Moody algebra [unk] with a symmetrizable Cartan matrix, generalizing the Weyl-Kac character formula [Kac, V. G. (1974) Funct. Anal. Appl. 8, 68-70]...

The population of Linxian in north central China is at high risk for gastric cardia adenocarcinoma (GCC) and esophageal squamous cell carcinoma (ESCC), and chronic inflammation may contribute to this risk. Interleukin-8 (IL8), a potent chemoattractant, has three well-characterized single nucleotide polymorphisms (SNP), one ( 251) of which alters transcriptional activity. Four well-described SNP...

PURPOSE We previously demonstrated that overexpression of interleukin 8 (IL-8) in human transitional cell carcinoma (TCC) resulted in increased tumorigenicity and metastasis. This increase in tumor growth and metastasis can be attributed to the up-regulation in the expression and activity of the metalloproteinases MMP-2 and MMP-9. EXPERIMENTAL DESIGN To investigate whether targeting IL-8 with...

Objective: To explore the patients with liver cirrhosis complicated by abdominal cavity infection IL8 and IL10 and serum calcitonin original value (PCT) in clinical examination. Methods: From July 2016 to February 2017, collected from digestive internal medicine diagnosis of liver cirrhosis associated with Spontaneous Bacterial Peritonitis (SBP) 50 cases; Simple ascites liver cirrhosis 50 cases...

aim : we investigated whether the level of il8 was different in patients with chronic and acute toxoplasma gondii infection during the pregnancy compared with control group. background : it is well established that t.gondii infection induces a strong cell-mediated immune response. patients and methods : elisa was used to determine the level of il8 in sera of 568 pregnant women. patients were di...

UNLABELLED Gene expression technologies allow the analysis of gene networks whose expression is associated with specific pathological conditions compared with normal tissue. We hypothesized that histologically normal tissue obtained in different ways (percutaneous or surgical liver biopsies), usually used as normal controls in gene expression studies, could have different gene expression patter...