نتایج جستجو برای: il28b genotype

تعداد نتایج: 91816  

Journal: :Hepatology 2012
Susanna Naggie Anu Osinusi Antonios Katsounas Richard Lempicki Eva Herrmann Alexander J Thompson Paul J Clark Keyur Patel Andrew J Muir John G McHutchison Joerg F Schlaak Martin Trippler Bhavana Shivakumar Henry Masur Michael A Polis Shyam Kottilil

UNLABELLED Recent studies have shown that a single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene plays a major role in predicting therapeutic response in hepatitis C virus (HCV)-infected patients treated with pegylated interferon (PEG-IFN)/ribavirin. We sought to investigate the mechanism of the IL28B polymorphism, specifically as it relates to early HCV viral kinetics, I...

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2013
Ana Luiza Dias Angelo Lourianne Nascimento Cavalcante Kiyoko Abe-Sandes Taísa Bonfim Machado Denise Carneiro Lemaire Fernanda Malta João Renato Pinho Luiz Guilherme Costa Lyra Andre Castro Lyra

OBJECTIVES Suppressor of cytokine signaling 3, myxovirus resistance protein and osteopontin gene polymorphisms may influence the therapeutic response in patients with chronic hepatitis C, and an association with IL28 might increase the power to predict sustained virologic response. Our aims were to evaluate the association between myxovirus resistance protein, osteopontin and suppressor of cyto...

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2015
Ahmed Al-Qahtani Mashael Al-Anazi Ayman A Abdo Faisal M Sanai Waleed Al-Hamoudi Khalid A Alswat Hamad I Al-Ashgar Mohammed Q Khan Ali Albenmousa Nisreen Khalaf Nisha Viswan Mohammed N Al-Ahdal

Recent studies have demonstrated that polymorphisms near the interleukin-28B (IL-28B) gene could predict the response to Peg-IFN-a/RBV combination therapy in HCV-infected patients. The aim of the study was to correlate the serum level of IL28B in HCV-infected patients with virus genotype/subgenotype and disease progression. IL28B serum level was detected and variations at five single nucleotide...

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2012
Jennifer M. Reynolds Sara A. Paciga Frances A. Sanders Craig L. Hyde A. Katrina Loomis Geoffrey I. Johnston

Several SNPs located in or around the IL28B gene are associated with response of patients infected with Hepatitis C virus to treatment with pegylated interferon-α ⁺/⁻ ribavirin or with spontaneous clearance of the virus. The results of such studies are so compelling that future treatment approaches are likely to involve clinical decisions being made on the basis of a patient's genotype. Since I...

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Journal: :The Journal of infectious diseases 2011
Pablo Barreiro Juan Antonio Pineda Norma Rallón Susanna Naggie Luz Martín-Carbonero Karin Neukam Antonio Rivero José Miguel Benito Antonio Caruz Eugenia Vispo Angela Camacho José Medrano John McHutchison Vincent Soriano

BACKGROUND Single-nucleotide polymorphisms (SNPs) near the IL28B gene have recently been associated with spontaneous hepatitis C virus (HCV) clearance and response to interferon-based therapies in patients with chronic hepatitis C. Because human immunodeficiency virus (HIV) coinfection appears to accelerate HCV-related liver fibrosis progression, any influence of IL28B SNP on the risk of develo...

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2011
Derek D. Cyr Joseph E. Lucas J. Will Thompson Keyur Patel Paul J. Clark Alexander Thompson Hans L. Tillmann John G. McHutchison M. Arthur Moseley Jeanette J. McCarthy

INTRODUCTION Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response to pegIFN/RBV in chronic hepatitis C (CHC) patients. The molecular consequences of this genetic variation are unknown. To gain further insight into IL28B function we assessed the association of rs12979860 with expression of ...

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Journal: :Antiviral therapy 2011
Alessandra Mangia Rosanna Santoro Roberto Sarli Leonardo Mottola Valeria Piazzolla Daniela Petruzzellis Donato Bacca Rocco Clemente Massimiliano Copetti Lazzaro di Mauro Giuseppe Lotti Michele Sacco Ippazio Stefano

BACKGROUND A single nucleotide polymorphism (SNP), upstream of the IL28B gene has been recently associated with natural clearance of HCV. In a well-characterized cohort of patients with thalassaemia major exposed to the risk of acquiring HCV infection by blood transfusions, we aimed to replicate this finding and to evaluate whether combining the IL28B genotype and HLA class II alleles allow vir...

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Journal: :Annals of hepatology 2014
Hikmet Akkiz Sedef Kuran Ersin Akgöllü Oguz Usküdar Aynur Bekar Süleyman Bayram

BACKGROUND AND AIM Multiple risk factors lead to hepatocellular carcinoma (HCC) including viral infections, mutation and single nucleotide polymorphisms (SNPs). Interleukin 28B (IL28B) gene rs12979860 polymorphism has been shown to be associated with HCC in the different populations, but its association with HCC has not been investigated in the Turkish population. We investigated whether the rs...

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2014
Nae-Yun Heo Young-Suk Lim Woochang Lee Minkyung Oh Jiyun An Danbi Lee Ju Hyun Shim Kang Mo Kim Han Chu Lee Yung Sang Lee Dong Jin Suh

BACKGROUND/AIMS There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. METHODS This was a retrospective cohort study of 156 patients with chronic hepatitis C viru...

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Journal: :gastroenterology and hepatology from bed to bench 0
seyed dawood mousavi nasab department of microbiology, faculty of medicine, kashan university of medical sciences, kashan, i.r. iran. rasoul baharlou department of microbiology, jahrom university of medical sciences, jahrom, iran ahmad piroozmand department of microbiology, faculty of medicine, kashan university of medical sciences, kashan, i.r. iran.autoimmune diseases research center, school of medicine, kashan university of medical sciences, kashan, iran. hadi toghyani department of virology, school of public health, tehran university of medical sciences, tehran, iran enayatollah shadmand department of microbiology, jahrom university of medical sciences, jahrom, iran hadi fazel department of virology, school of public health, tehran university of medical sciences, tehran, iran

aim : the purpose of this study was to compare the distribution of interleukin (il)-28b genotypes between iranian healthy individuals and patients with chronic hepatitis c based on the genotype. background : polymorphisms in the region of il-28b gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (svr) in hepatitis c infection. patients an...

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