نتایج جستجو برای: il1α
تعداد نتایج: 93 فیلتر نتایج به سال:
Interleukin-1 (IL-1) play its role in inflammation, fever and release of acute phase proteins by acting on major organs of the body. IL1α gene along with other cytokines compels Th1 and Th17 inflammatory responses. The present study is aimed at standardization of polymerase chain reaction for amplification of IL-1α gene from bovine peripheral blood mononuclear cells. Blood samples were collecte...
Abstract Notch activation has been detected in pancreatic ductal adenocarcinoma (PDAC). However, its role PDAC metastasis remains unknown. In this study, we identify a Notch-dependent feedback circuit between cancer cells and macrophages, which contributes to metastasis. circuit, miR-124 regulated signaling by directly targeting the ligand Jagged 1. Autoamplified promoted recruitment of macroph...
Osmotic demyelination syndrome is a devastating neurologic condition that occurs after rapid correction of serum sodium in patients with hyponatremia. Pathologic features of this injury include a well-demarcated region of myelin loss, a breakdown of the blood-brain barrier, and infiltration of microglia. The semisynthetic tetracycline minocycline is protective in some animal models of central n...
Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone marks critical for cancer development is of particular importance. Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates histone H3 on lysine 23/36/37 residues, which specifically recruits histone acety...
Objectives: The aim of this study was to compare the concentration of tumor necrosis factor α, interleukin 1α, 6, and 8 in the saliva of oral squamous cell carcinoma patients with control group. Study design: In this study 18 subjects were involved, nine patients with oral squamous cell carcinomas and nine age-sex-matched healthy individuals that were matched for gingival conditions too. Active...
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