نتایج جستجو برای: il 27
تعداد نتایج: 293861 فیلتر نتایج به سال:
background: interleukin-27 is a heterodimeric cytokine belonging to il-12 and il-23 families, secreted by antigen presenting cells( apcs ) .the il-27 is composed of 2 subunits: epstein-barr virus induced gene 3 (ebi3) and p28. il-27 is an anti-inflammatory cytokine which has an inhibitory effect on th17 population and suppress the il-17 expression. it is suggested that il-27 could be a potent ...
objective: autoimmune diseases precede a complex dysregulation of the immune system. t helper17 (th17) and interleukin (il)-17 have central roles in initiation of inflammation and subsequent autoimmune diseases. il-27 significantly controls autoimmune diseases by th17 and il-17 suppression. in the present study we have created genetic engineered mesenchymal stem cells (mscs) that mediate with l...
background: in this study the level of il-23 and il-27 produced by macrophages derived from peripheral blood mononuclear cell culture collected from patients with healing or non-healing form of cutaneous leishmaniasis lesion were compared before and after treatment with live leishmania to explore whether il-23 or il-27 plays any role in healing process of cutaneous lesions induced by l. major...
IL-27 exerts antitumor activity in murine orthotopic neuroblastoma, but only partial antitumor effect in disseminated disease. This study demonstrates that combined treatment with IL-2 and IL-27 induces potent antitumor activity in disseminated neuroblastoma metastasis. Complete durable tumor regression was achieved in 90% of mice bearing metastatic TBJ-IL-27 tumors treated with IL-2 compared w...
Background and Objective: Breast cancer, assumed as a difficult -to –treat disorder across the world, is the most common malignancy among women. Over decades, significant advances in breast cancer immunotherapy and tumor immune biology have been brought about. In vitro studies of the effect of various cytokines have been conducted in breast tumor. Among Interleukins, IL-27 -a novel cytokine- is...
IL-27 is a member of the IL-6/IL-12 family and activates both STAT1 and STAT3 through its receptor, which consists of WSX-1 and gp130. We previously demonstrated that IL-27 has potent antitumor activities, which are mediated through CD8(+) T cells, NK cells, or its own antiangiogenic activity. In this study, we demonstrate that IL-27 also possesses a direct antiproliferative activity on melanom...
background the immune system plays important roles in determining the outcomes of hepatitis c virus (hcv) infection. interleukin-23 and -27 (il-23 and il-27) are two novel il-12 cytokine family members known to enhance the t-lymphocyte response, but their precise involvement in hcv infection is not well known. objectives we investigated the serum il-27 and il-23 levels in patients with hcv infe...
چکیده: اینترلوکین 27il-27) (یک سایتوکاین جدید است که یکی از اعضای مشترک خانواده های اینترلوکین 12و 23 به حساب می آید و به وسیله سلول های عرضه کننده آنتی ژن (apcs) ترشح میشود. هترو دایمری شامل دو سابیونیت p28و(ebi3) epstein-barr-induced gene 3 است. مطالعات اخیر ظرفیت های جدیدی را برای il-27 از جمله تحریک خون سازی، افزایش بروز آنتی بادی یه وسیله سلول های عرضه کننده آنتی بادی آنتی بادی(apcs)، سرک...
Background and purpose: In multiple sclerosis (MS) and its murine model, experimental autoimmune encephalomyelitis (EAE), chronic inflammation damages the myelin of central nervous system. Recently, interleukin-27 (IL-27) has been recognized as a feasible choice for treatment of autoimmune diseases such as MS due to its anti-inflammatory properties. However, the underlying mechanisms have not y...
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