نتایج جستجو برای: iguratimod
تعداد نتایج: 69 فیلتر نتایج به سال:
T-614 (also named as iguratimod), a novel antirheumatic drug, could attenuate joint inflammation and articular damage in rheumatoid arthritis (RA) patients, providing a new therapy for RA. Here, we tested the role T-614 on the IL-6-induced receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG), IL-17, and MMP-3 expression in synovial fibroblasts from rheumatoid arthritis (...
Background At present, specific immune targeted therapeutics including biologics and kinase inhibitors has made significant progress in Rheumatoid arthritis (RA). However, the irresponse to therapies some refractory RA patients suggests more attention should be paid on cell death pathways, such as pyroptosis. TNF-α is a proinflammatory cytokine that plays fundamental role pathogenesis of RA, wh...
Objective: The objective of the work was to develop and validate stability indicating HPTLC method for estimation Iguratimod. Methods: employed aluminium pre-covered silica gel 60 GF254 plates (10 cm × 10 with 250 μm layer thickness) as stationary phase while solvent system n-Hexane: Ethyl Acetate (5:5 v/v) densitometric scanning at 256 nm. Sample applied a band 8 mm width using Camag 100 μl sa...
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