Earlier work indicated that Tomato spotted wilt virus (TSWV) messenger transcripts, and not the (anti)genomic RNAs, are targeted by the RNA silencing machinery. Here, the predicted AU-rich hairpin (HP) structure encoded by the intergenic region (IGR) of the TSWV S RNA, and present at the 3' end of viral mRNAs, was analyzed as a target and inducer for RNA silencing. Virus-derived siRNAs (vsiRNAs...

The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae viral family can directly assemble 80S ribosomes and initiate translation at a non-AUG codon from the ribosomal A-site. These functions are directed by two independently folded domains of the IGR IRES. One domain, composed of overlapping pseudoknots II and III (PKII/III), mediates ribosome recruitment. The seco...

We present the results of our optical spectrophotometric campaign ongoing at the Astronomical Observatory of Bologna in Loiano (Italy) on hard X-ray sources detected by INTEGRAL. We observed spec-troscopically the putative optical counterparts of four more INTEGRAL sources, IGR J12391−1610, IGR J18406−0539, 2E 1853.7+1534 and IGR J19473+4452. These data have allowed us to determine their nature...

Results of analysis of RXTE observations of strongly absorbed X-ray sources IGR J16318-4848 and IGR J16358-4726 are presented. Careful subtraction of Galactic ridge emission contribution to the observed spectra of RXTE/PCA allowed us to obtain the spectra of the sources in 3–25 keV energy band. Spectra of the sources cold be well described by a power law with photoabsorption. It is shown that t...

BACKGROUND AND PURPOSE Initial diffusion-weighted imaging lesion growth rate (IGR) assessed by diffusion-weighted imaging lesion volume divided by the delay from onset to magnetic resonance imaging offers an estimate of early brain infarction progression. We investigated the impact of IGR on the rate of favorable outcome according to the occurrence of a successful endovascular revascularization...

OBJECTIVE Newer generation left ventricular assist devices (LVADs) are established for long-term support. The aim of this multi-modal intervention was to improve the body weight, exercise tolerance and psychosocial status in outpatients on long-term LVAD support. METHODS Seventy patients participated in this non-randomized intervention study [intervention group (IGr) n = 34; control group (CG...

Effective and accurate diagnosis of Diabetes Mellitus (DM), as well as its early stage Impaired Glucose Regulation (IGR), has attracted much attention recently. Traditional Chinese Medicine (TCM) [3], [5] etc. has proved that tongue, face and sublingual diagnosis as a noninvasive method is a reasonable way for disease detection. However, most previous works only focus on a single modality (tong...

INTRODUCTION Autonomic dysfunction has been theorized to be responsible for the increased risk of cardiovascular disease in obstructive sleep apnea (OSA). Previous studies did not control for the presence of impaired glucose regulation (IGR, comprising impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes) which is also associated with abnormalities in autonomic functio...

In our continuing optical spectroscopic campaign to identify the longer-wavelength counterparts of newly-discovered hard X–ray sources detected by INTEGRAL, we observed the putative optical counterparts of seven southern sources at the South African Astronomical Observatory and at the European Southern Observatory. For two of these objects, optical photometry was also acquired. These observatio...

We studied spectra for 34 accretion-powered X-ray and one millisecond pulsars that were within the field of view of the INTEGRAL observatory over two years (December 2002–January 2005) of its in-orbit operation and that were detected by its instruments at a statistically significant level (> 8σ in the energy range 18–60 keV). There are seven recently discovered objects of this class among the p...