Background: Liver cirrhosis is one of the most significant causes death in many regions worldwide. This study aimed to assess correlation hemostatic and endocrine parameters with Child-Turcotte-Pugh (CTP) scoring patients non-alcoholic liver cirrhosis. Materials Methods: included 59 monitored for a gastroenterology clinic from January 2018 February 2019. The subjects were grouped according CTP ...

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...

Severe cardiovascular diseases, such as myocardial infarction or heart failure, can alter thyroid hormone (TH) secretion and peripheral conversion, leading to low triiodothyronine (T3) syndrome. Accumulating evidence suggests that TH has protective properties against diseases treatment with effectively reduce damage after (MI). Our aim is investigate the effect of T3 pretreatment on cardiac fun...

BACKGROUND: Airway remodeling in children with bronchial asthma is due to the effect of inflammatory mediators and growth factors on epithelium. Vitamin D (VitD) has immunomodulatory many diseases as asthma. The ant-inflammatory anti-fibrotic role VitD could prevent or improve air way asthmatic patients. AIM: study investigated supplementation expression transforming factor-beta (TGF-β), tumor ...

Abstract Acromegaly is a rare, chronic disease that is, in more than 95% of cases, caused by growth hormone (GH)-secreting pituitary adenoma. Overproduction insulin-like factor-1 (IGF-1) due to GH hypersecretion leads various clinical features characterized somatic overgrowth, physical changes, multiple comorbidities, and increased mortality. The average age at diagnosis 40 50 years, with no se...

conclusions our findings indicated a lower level of both omentin-1 and igf-1 in women with mets; this might play a role in the pathogenesis of mets. furthermore, the main finding of the current investigation was the association between omentin, visfatin and igf-1; however determining the molecular mechanism of the observed relationships needs further studies. results significantly lower levels ...

the insulin-like growth factor i receptor (igf-ir) plays an essential role in the establishment and maintenance of transformed phenotype. interference with the igf-ir pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. we stably transfected the pc-3 human prostate cancer cell line with an igf-ir antisense rna expression plasmid. the numbe...