نتایج جستجو برای: ifnl4
تعداد نتایج: 81 فیلتر نتایج به سال:
Interferon lambda 4 gene (IFNL4) encodes IFN-l4, a new member of the IFN-l family with antiviral activity. In humans IFNL4 open reading frame is truncated by a polymorphic frame-shift insertion that eliminates IFN-l4 and turns IFNL4 into a polymorphic pseudogene. Functional IFN-l4 has antiviral activity but the elimination of IFN-l4 through pseudogenization is strongly associated with improved ...
Abstract Background In non-uremic subjects, IFNL4 rs368234815 predicts HCV clearance. We investigated whether is associated with spontaneous clearance in haemodialysis patients and it a stronger predictor of resolution than the IFNL polymorphisms already dialysis subjects. also evaluated an association patients` survival alterations transcription factor binding sites (TFBS) caused by polymorphi...
Chronic hepatitis C virus (HCV) infection can now be treated with oral directly acting antiviral agents, either with or without ribavirin (RBV). Virologic relapse after treatment can occur, and in some studies was more common in cirrhotic subjects. We previously observed changes in hepatic immunity during interferon (IFN)-free therapy that correlated with favourable outcome in subjects with ear...
Address correspondence to: Esther A. Torres, MD, Gastroenterology Research Unit, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR. Email: [email protected] Objective: To describe the risk factors for infection, complications, treatment received and response in Puerto Ricans with HCV attending gastroenterology clinics at UPR-MSC, and the prevalence ...
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a coho...
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