Spontaneous abortion is the most common complication of pregnancy. Several lines of evidence indicate that immunologic effector cells may play a role in the pathogenesis of idiopathic repetitive abortions. Leukocytes form a substantial proportion of stromal cells in decidua and the endometrial granulated lymphocytes (eGL) is the predominant decidual leukocyte population in the first trimester o...

Recurrent abortion is classically defined as three or more consecutive pregnancy losses, although recently more than two pregnancy losses also considered as recurrent abortions. This condition affects approximately 1% of couples at reproductive age. Recurrent pregnancy loss has been attributed to anatomic uterine pathologies, genetic defects, endocrine disorders, immunologic factors, prothrombo...

A fine balance between coagulation and fibrinolysis is critical in early pregnancy. Plasminogen activator inhibitor-1 (PAI-1) and angiotensin converting enzyme (ACE) are involved in the fibrinolytic process, and several studies have reported the association between their gene polymorphisms and recurrent pregnancy loss (RPL). This study was conducted to investigate the association between PAI-1 ...

this study was conducted in order to investigate the association between the single nucleotide polymorphism (snp) rs2305957 g/a and recurrent pregnancy loss (rpl) in a group of palestinian women residing in gaza strip. a retrospective case-control study was carried out during the period of may to august 2015. a total of 380 females including 190 recurrent pregnancy loss (rpl) patients and 190 c...

Recurrent pregnancy loss (RPL) refers to the consecutive loss of three or more clinically recognized pregnancies prior to the 20th week of gestation (excluding ectopic, molar and biochemical pregnancies). RPL is classified into two categories: primary RPL, which consists of repeated miscarriages in which a pregnancy has never been carried to viability; and secondary RPL, in which a live birth h...

conclusions: we determined a significant higher frequency of protein s deficiency in patients with rpl compared with controls. but the frequency of protein c deficiency and the frequency of two common thrombophilic mutations (factor v leiden and prothrombin g20210a), were not significantly different between patients with recurrent miscarriage and healthy women. results: the mean functional acti...