BACKGROUND Membranous nephropathy is a common cause of the nephrotic syndrome. Treatment with standard regimens fails to induce complete remission in most patients. We evaluated the efficacy of combination therapy with rituximab, low-dose, oral cyclophosphamide, and an accelerated prednisone taper (RCP) for the treatment of idiopathic membranous nephropathy. METHODS We analyzed 15 consecutive...

In the fifties and the sixties, ACTH was widely used for the treatment of childhood nephrosis probably caused by minimal change disease in most cases [1,2]. This treatment was provided in lieu of steroids since it does not suppress the adrenal glands and there were hopes of less growth stunting. There are a few reported cases of ACTH treatment in nephrotic patients who had not been biopsied but...

We describe a case of a 55-year-old man who presented with pulmonary embolism and who was found to have nephrotic syndrome due to idiopathic membranous nephropathy. There are no other signs of nephrotic syndrome such as edema.

BACKGROUND Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membranous nephropathy, we examined the value of baseline EF-IgG in predicting rem...