believe it is important to consider the possibility that prolonged “postictal” deficits may be due to ongoing ictal discharges, as additional anticonvulsant medication may be indicated. There were rare periods in this case when there were subtle pseudoperiodic discharges on the scalp EEG during ongoing ictal activity intracranially, and persistent aphasia. This supports the view that in some in...

Identification of the epileptic focus is the most important requirement for a successful surgical outcome in intractable epilepsy. Patients with normal MRI on high-resolution imaging pose a significant challenge in this regard. We tried to identify the epileptic focus using interictal / ictal SPECT and ictal EEG patterns in 14 patients with normal MRI. Rhythmic ictal onset activity helped to id...

Because seizures originate from different pathological substrates, the question arises of whether distinct or similar mechanisms underlie seizure generation across different pathologies. Better defining intracranial electroencephalographic morphological patterns at seizure-onset could improve the understanding of such mechanisms. To this end, we investigated intracranial electroencephalographic...

background: the existence of a pathophysiological link between headaches and muscle activity pattern is still being debated. the purpose of this study was to investigate the effect of pain on the timing pattern of the masseter muscle in patients with tension-type headache (tth) and migraine without aura (moa). methods: 57 women (22 controls, 19 moa and 16 tth) participated in the study. the ele...

Epileptic seizures are associated with neuronal hyperactivity. Here, however, we investigated whether continuous neuronal firing is necessary to maintain electrographic seizures. We studied a class of "low-Ca2+" ictal epileptiform bursts, induced in rat hippocampal slices, that are characterized by prolonged (2-15 s) interruptions in population spike generation. We found that, during these inte...

Benign myoclonic epilepsy in infancy (BMEI) is a rare syndrome included among idiopathic generalized epilepsies (IGE) and syndromes with age-related onset. Recently, it has been shown that a few patients with BMEI later had other epilepsy types mainly IGE but never childhood absence epilepsy (CAE). We report a patient who at 11 months of age showed isolated myoclonic jerks occurring several tim...

PURPOSE Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propagation of ictal MEG activity in patients with neocortical epilepsy. METHODS...

BACKGROUND Precise control of anesthetic depth during electroconvulsive therapy (ECT) is crucial because most intravenous anesthetics have anticonvulsant effects. In this study, we investigated the association between anesthetic depth measured by the Alaris auditory evoked potential index (AAI) and seizure inducibility and seizure duration during ECT. METHODS Sixty-four ECTs were evaluated in...

Population spikes vary in size during prolonged epileptic (“ictal”) discharges, indicating variations in neuronal synchronisation. Here we investigate the role of changes in tissue electrical resistivity in this process. We used the rat hippocampal slice, low Ca model of epilepsy and measured changes in pyramidal layer extracellular resistance during the course of electrographic seizures. Durin...