BACKGROUND The DAOA/G30 (D-amino acid oxidase activator) gene complex at chromosomal region 13q32-33 is one of the most intriguing susceptibility loci for the major psychiatric disorders, although there is no consensus about the specific risk alleles or haplotypes across studies. METHODS In a case-control sample of German descent (affective psychosis: n = 248; controls: n = 188) we examined s...

OBJECTIVE: Diabetes mellitus is one of the most challenging global health problems in 21st century. In this study, we aimed to identify some risk factors by analyzing diabetes records.MATERIAL AND METHODS: This a descriptive and retrospective study. Data were obtained from hospital records. The population study consisted 34.649 cases who applied three state hospitals between August 1, 2005, Jan...

We have studied the prevalence of comorbidity in the Stockholm EPR corpus containing almost 600,000 patients from 900 clinics using the ICD10 codes assigned to each patient record. The proportion of patients with a valid ICD-10 code was 83.0%, and 41.5% of these had at least one comorbidity. The most frequent comorbidity combination with type 2 diabetes was essential hypertension (43.1%). Our a...

Methods Over a three-year period (April 2011 to April 2014), data were collected on anaphylaxis cases at the Montreal Children’s Hospital emergency department (ED). Cases were recruited either prospectively or identified retrospectively based on chart review through ICD10 codes related to anaphylaxis. Logistic regressions were conducted to determine the association between sociodemographic and ...

background and purpose: mortality statistics and rates show the development of a country in the world. these statistics are very important for determining the distribution of risk factors of mortality (in age and gender groups, ethnicity and so on) and they are useful for improving health and preventing from important diseases in future planning of countries in societies. materials and methods:...

METHODS Participants selected from the on-going Finnish 10-town study comprised all 46 569 full time municipal employees who had a job contract lasting a minimum of three full consecutive years between 1 January 1990 and 31 December 2000, and were below 55 at the end of the follow up, the age before which medical causes exclusively determine granting of disability pension for municipal employee...

Revisions of the International Classification of Diseases (ICD) can lead to biases in cause-specific mortality levels and trends. We propose a novel time series approach to bridge ICD coding changes which provides a consistent solution across causes of death. Using a state space model with interventions, we performed time series analysis to cause-proportional mortality for ICD9 and ICD10 in the...

Electronic patient records are a potentially rich data source for knowledge extraction in biomedical research. Here we present a method based on the ICD10 system for text-mining of Danish health records. We have evaluated how adding functionalities to a baseline text-mining tool affected the overall performance. The purpose of the tool was to create enriched phenotypic profiles for each patient...

BACKGROUND To determine the clinical effectiveness of statins on cardiovascular mortality in practice, observational studies are needed. Control for confounding is essential in any observational study. Falsification end-points may be useful to determine if bias is present after adjustment has taken place. METHODS We followed starters on statin therapy in the Netherlands aged 46 to 100 years o...

In this working notes paper, we present our methodology and the results for Task 1 of the CLEF eHealth Evaluation Lab 2017. This benchmark addresses information extraction in written text with focus on unexplored languages corpora, specifically English and French. The goal is to automatically assign codes (ICD10) to text content of death certificates. Our approach is focused on fusion methods i...