Abstract Background Von Willebrand disease (VWD) is an autosomal recessive congenital bleeding disorder with deficiency or dysfunction of von Willebrand factor (VWF). The gene encoding for the VWF is located on chromosome 12, which is 178 Kb with 52 exons. Various mutations of this gene is responsible for the clinical features of VWD, but some single nucleotide polymorphisms make the molecu...

Genetic improvement programs may improve disease resistance in animal production. The best-characterized genetic control of disease resistance and immune response in animals is the one associated with the Major Histocompatibility Complex (MHC). The ovine lymphocyte antigenof DRB1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

Background: KDM3A is a key epigenetic regulator that is expressed in the testis and is required for packaging and condensation of sperm chromatin. To this point, the association of the KDM3A gene and infertility has not been studied in human. The aim of this study was to screen any new mutation in KDM3A gene to explore more details of human male infertility. Methods: In this work, 150 infertile...

Growth hormone (GH) is the most important hormone that controls somatic cell growth and the syntheses of protein, fat, and carbohydrates. This study was to identify gene polymorphism of GH-1 using PCR- single strand conformation polymorphism (SSCP) technique and its association with growth traits including condition factor (CF), body weight (BW) and total length (TL) in common carp (Cyprinus ca...

Glutathione S-transferases (GSTs) are a major family of detoxification enzymes which possess a wide range of substrate specificities. Interest in insect GSTs has primarily focused on their role in insecticide resistance. In this study, following World Health Organization (WHO) routine susceptibility test, DNA was extracted from specimens of Anopheles stephensi collected from the Kazeroon distri...

in this study, 100 moghani sheep from breeding station located in jaafarabad, moghan were genotyped for exon 1 of igf-i gene, using pcr-sscp. different band patterns were obtained in this site gene that was studied. based on sscp patterns, three genotypes bc, bd and bb obtained with frequencies of 65%, 26% and 9%, respectively. the genotype frequencies had a significant deviation from hwe. in a...

the current study was designed to estimate the frequency of igf-i gene 1 polymorphism and investigate if their polymorphisms have association with biometric traits in moghani sheep by pcr-sscp method. for this purpose, a number of 100 sheep were randomly chosen from moghani sheep jafarabad, moghan breeding station that located in ardabil state and blood samples were collected from the left jugu...

<Anopheles culicifacies is a main malaria vector in southeastern part of Iran, bordring Afghanistan and Pakistan. So far, resistance to DDT, dieldrin, malathion and partial tolerance to pyrethroids has been reported in An. stephensi, but nothing confirmed on resistance status of An. culicifacies in Iran. Methods: In current study, along with WHO routine susceptibility test with DDT (4%), di...

Introduction: Association between single-nucleotide polymorphisms (SNPs) in mu opioid receptor gene and drug addiction has been shown in various studies. Here, we have evaluated the existence of polymorphisms in exon 3 of this gene in Iranian population and investigated the possible association between these mutations and opioid addiction.  Methods: 79 opioid-dependent subjects (55 males, 24...