Effective haemodialysis (HD) requires a reliable vascular access (VA). Clinical practice guidelines strongly recommend the arteriovenous fistula (AVF) as the preferred VA in HD patients. The creation of an AVF should be promoted in all eligible patients who choose HD, as it improves outcomes and reduces costs when compared with central venous catheters. Fistula eligibility is a 'work in progres...

Taking as its starting point a 1978 article by film critic Molly Haskell, in which she described Gérard Depardieu “tactile […] grasping, eating, touching, coming to physical terms with everything sight”, this considers largely overlooked role, the committed revolutionary leader Georges Danton Andrzej Wajda’s (1983)—a historical role that reflects actor’s commitment relevance of Revolutionary po...

Cathy R. Taylor, Joseph T. Hepworth, Peter I. Buerhaus, Robert Dittus, Theodore Speroff Vanderbilt University School of Nursing, VA Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center (GRECC), VA THVS Health Services Research Center for Patient Healthcare Behavior, VA National Quality Scholars Fellowship Program, Vanderbilt University School of Medi...

The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form of ROS produced during I/R, causes inflammation, apoptosis and subsequent tissue damages. Here, we report H2O2-responsive antioxidant nanoparticles formulated from copolyoxalate containing vanillyl alcohol (VA) (PVAX) ...

VA-RNA I is one of the very few RNA species produced in animal cells whose transcriptional initiation site is known precisely. We have analyzed the nucleotide sequence of the DNA preceding the 5' end of VA-RNA I and compared it with known prokaryotic promoters and presumptive eukaryotic promoters.

BACKGROUND Catheter ablation for ventricular arrhythmia (VA) near the distal great cardiac vein (GCV) is often challenging, and data are limited. METHODS AND RESULTS Analysis was performed in 30 patients (19 men; age, 52.8±15.5 years) who underwent catheter ablation for focal VA (11 ventricular tachycardia and 19 premature contractions) with early activation in the GCV (36.7±8.0 ms pre-QRS). ...

The effects of nitrooxy alkyl apovincaminate VA-045 ((+)-eburunamenine-14-carboxylic acid(2-nitroxy-ethyl ester), VA) were investigated in acutely dissociated rat neocortical neurons by using a nystatin-perforated patch recording configuration. VA activated a steady-state outward current in a concentration-dependent manner, with an EC50 of 0.65 microM. The reversal potential for the current shi...

thus the data show a re lationship between radiation and the development of thyroid ca rci noma and i mp l y that s eeking and r emoving such tumors woul d be beneficial . as in most situations, however, this s i mp l e r elationship is clouded by a va r i e t y of associated prob l ems , which mus t be ca r efull y considered. the surgical pr oce dure r e c ommended f or r emoval o f a nodule ...