What has MCPH got to do with the evolution of human intelligence? It has been suggested that small, cumulative changes in MCPHassociated genes have collectively led to the increase in human brain size. There is a clear relationship between measurable intelligence and brain size within humans and between other mammals. Broadly speaking, herbivores have smaller brains than predators and scavenger...

Introduction . Chronic pain syndrome in the development of malignant neoplasms has a complex polyethological character. The study pathogenetic mechanisms during growth transplanted tumor experiment can open up broad perspectives for creation new domestic analgesic drugs use oncology. Aim : To serotonin inactivation coefficient (SIC), ratio (S) and its main metabolite 5-hydroxyindolacetic acid (...

Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain str...

Today, obesity is the most urgent unsolved medical problem, with the threat of a decreased life expectancy rate for the first time in medical history. Many obese subjects try to lose weight by dieting and exercising, without success on a long term basis. The only therapy with some effect is bariatric surgery with the impact of sustainable adverse effects only suitable in morbid obesity. Why are...

Abstract Objectives: The purpose of this study was to investigate whether stress affected energy metabolism and reproductive function through the glucocorticoid receptor (GR) on Kisspeptin neurons in hypothalamus. Methods: 1. first part focused effects chronic restraint mice. 2. second expression serum cortisol prolactin GR Kiss1 genes hypothalamus.3. Based above research, we constructed specif...

Expression of microRNAs in the hypothalamus pregnant and non-pregnant goats | Lu Zhu, Jingtong Huang, Jing Jing, Qi Zheng, Qianyun Ji, Ya Liu, Jianping Ding, Fugui Fang, Yunsheng Li, Yunhai Zhang, Yinghui Ling Agricultural Journals

Background: Depression is a typical psychosomatic disease. Shuganheweitang (SGHWT) clinical formula that effectively treats depression. However, the potential mechanism used by SGHWT to ameliorate depression-like behaviors still unclear. This study investigated effects of on metabolic change in liver and hypothalamus with signaling pathways involved chronic unpredictable mild stress (CUMS)-indu...