Hypophyseal tumors occur rarely in mice. Only one mouse among 11,000 autopsied in Dr. Slye's laboratory showed a hypophyseal tumor.11 A chromophobe-cell adenoma of the pituitary gland was reported in a mouse which had bilateral granulosa-cell tumors of the ovaries.6 This animal also showed evidence of hyperestrogenic stimulation, as indicated by multiple mammary tumors and uterine glandular cys...

Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varie...

The hypothalamus receives neuronal afferents from numerous sources including inputs from limbic structures, such as the amygdala and hippocampus, and from brainstem regions involved in the regulation of the cardiovascular system and other autonomic functions. These afferents using a vast array of neurotransmitters and neuropeptides influence the activity of the hypothalamic neurons which synthe...

By acting through its receptors (RXFP1, RXFP2), relaxin (RLN) exerts species-specific effects during pregnancy; possible luteotropic effects through stimulation of prolactin (PRL) release have been suggested. In the domestic dog (Canis lupus familiaris) serum PRL increases in pregnant bitches shortly after RLN appears in the circulation, and a possible functional relationship between the RLN an...

A vertical conduit in the basisphenoid extending from the floor of the sella to the undersurface of this bone was observed in two children. There was no associated nasopharyngeal mass. A review of the literature on this defect and related subjects suggests a close relation between this lesion and transsphenoidal meningoencephalocele.

It is often implied that chromophobe adenomas of the hypophysis are without significant endo crine function (11). However, some hypophyseal tumors experimentally produced in mice by de stroying their thyroids with I131 have been de scribed as functioning chromophobe adenomas (9, 10). A review of the literature on the effects of thy roid deficiency in laboratory animals reveals wide discrepancie...

Sedimentation velocity was measured in a Spinco ultracentrifuge’ operating at 165,000 X g. The hormone solutions (0.5 per cent) were prepared with borate buffer of pH 9.7 or saline at pH 9.1. Table I presents a typical run in a borate buffer; the sedimentation velocity constant was calculated by the procedure described by Svedberg and Pedersen (3). It may be noted that the individual values of ...