BACKGROUND Concurrent chemoradiation therapy (CCRT) and transoral laser microsurgery (TLM) have become therapeutic selections for organ preservation in patients with hypopharyngeal cancer. METHODS Our cross-sectional, observational study assesses quality of life (QOL) in patients with hypopharyngeal cancers receiving TLM plus radiotherapy (RT) compared with those treated with CCRT only or rad...

AIM To define specific staining patterns for the adhesion/growth-regulatory lectin tandem-repeat-type galectin-8 in hypopharyngeal and laryngeal tumor progression and relate these parameters to galectins 1, 3 and 7 in the quest to explore the galectin network. MATERIALS AND METHODS The level of expression of galectin-8 was determined immunohistochemically in a series of 18 and 16 cases of tum...

Bile-containing gastro-duodenal reflux has been clinically considered an independent risk factor in hypopharyngeal carcinogenesis. We recently showed that the chronic effect of acidic bile, at pH 4.0, selectively induces NF-κB activation and accelerates the transcriptional levels of genes, linked to head and neck cancer, in normal hypopharyngeal epithelial cells. Here, we hypothesize that NF-κB...

OBJECTIVE We investigated the risk factors for metastasis to retropharyngeal lymph nodes (RPLNs) and the significance of dissection of RPLNs in hypopharyngeal cancer. Metastasis to the RPLNs is an important prognostic factor in head and neck cancer, especially in hypopharyngeal cancer. METHODS Study subjects were 129 cases who received primary treatment at nine leading medical facilities in t...

BACKGROUND From among a cohort of 65,553 men aged 30-84 in Karunagappally Taluk, Kerala, India, 52 hypopharyngeal cancer cases and 85 laryngeal cancer cases were identified by the Karunagappally Cancer Registry during the period between 1990 and 2009. METHODS We conduct Poisson regression analysis of grouped data, taking into account age and education. RESULTS This study showed that the inc...

HCLS1‑associated protein X‑1 (HAX‑1) is highly expressed or overexpressed in various types of human tumor, and its overexpression is associated with cancer metastasis and cellular proliferation. However, the precise molecular mechanism involved in HAX‑1‑associated proliferation and metastasis in hypopharyngeal carcinoma is unknown. The present study aimed to investigate the role of HAX‑1 in the...

Squamous cell carcinomas (SCC) of the larynx is the one of the most common cancers of the head and neck region, accounting for 2.4% of new malignancies and 0.7% of all cancer deaths worldwide every year [1]. Hypopharyngeal SCCs, although less common, carry a poor overall prognosis. Worldwide estimation of 5-year overall survival (OS) of laryngeal and hypopharyngeal cancers ranges from 32 to 70%...