نتایج جستجو برای: hypoperfusion ischemialtpmemoryrat

تعداد نتایج: 3472  

Journal: :Glia 2018
Yasmina Manso Philip R Holland Akihiro Kitamura Stefan Szymkowiak Jessica Duncombe Edel Hennessy James L Searcy Martina Marangoni Andrew D Randall Jon T Brown Barry W McColl Karen Horsburgh

Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown that cerebral hypoperfusion disrupts axon-glial integrity and the distribution of key paranodal and internodal proteins in subcortical myelinated axons. This disruption of my...

Journal: :Stroke 1993
A V Alexandrov C E Bladin J W Norris

BACKGROUND AND PURPOSE The value of acute cerebral blood flow measurements in stroke prognosis is controversial. No previous study has determined whether acute perfusion deficits independently add to a validated clinical prognostic score. We aimed to compare the value of acute hypoperfusion deficits with a quantitative clinical score in stroke prognosis and to correlate the changes in perfusion...

2017
Eszter Farkas Ádám Institóris Ferenc Domoki András Mihály Paul G.M. Luiten Ferenc Bari

Chronic cerebral hypoperfusion, a mild ischemic condition is associated with advancing age and severity of dementia; however, no unanimous therapy has been established to alleviate related neurological symptoms. We imposed a permanent, bilateral occlusion of the common carotid arteries of rats (n = 18) to create cerebral hypoperfusion. A mitochondrial ATP-sensitive K channel opener diazoxide (D...

2018
Hayato Takeuchi Masahiro Kameda Takao Yasuhara Tatsuya Sasaki Atsuhiko Toyoshima Jun Morimoto Kyohei Kin Mihoko Okazaki Michiari Umakoshi Ittetsu Kin Ken Kuwahara Yosuke Tomita Isao Date

Several reports have shown that long-term potentiation (LTP) per se effectively enhances neurogenesis in the hippocampus of intact animals. If LTP can enhance neurogenesis in chronic hypoperfusion, this approach could potentially become a new therapeutic strategy for the restoration of cognitive function and for prevention from deterioration of mild cognitive impairment (MCI). Using an in vivo ...

Journal: :Annals of nuclear medicine 2007
Hiroki Sasaki Kazunari Ishii Atsushi K Kono Naokazu Miyamoto Tetsuya Fukuda Kenichi Shimada Shingo Ohkawa Tetsuro Kawaguchi Etsuro Mori

OBJECTIVES To investigate the specific pattern of cerebral blood flow (CBF) in subjects with idiopathic normal pressure hydrocephalus (iNPH) using voxel-based analysis. METHODS N-isopropyl-p-[123I]iodoamphetamine (IMP) single photon emission computed tomography (SPECT) images were performed in 30 iNPH patients, who met probable iNPH criteria, 30 Alzheimer disease (AD) patients and 15 normal c...

2012
Won Kyung Jeon Jinhua Ma Bo-Ryoung Choi Seol-Heui Han Qinghao Jin Bang Yeon Hwang Jung-Soo Han

Fructus mume (F. mume) has been used as a medicinal food in Japan and has been reported to have anti-inflammatory effects in inflammatory bowel disease and macrophage-mediated inflammation. We investigated the effects of F. mume extracts on cognitive dysfunction in rats with chronic cerebral hypoperfusion and the molecular mechanisms underlying these effects. Chronic cerebral hypoperfusion was ...

Journal: :Stroke 1992
S M Davis J T Andrews M Lichtenstein S C Rossiter A H Kaye J Hopper

BACKGROUND AND PURPOSE Elevated middle cerebral erythrocyte velocities and tissue hypoperfusion have been correlated with delayed ischemia after subarachnoid hemorrhage, but few studies have compared serial arterial velocities with cerebral blood flow and neurological deficits. METHODS Serial measurements of middle cerebral velocities, using transcranial Doppler ultrasonography, were performe...

Journal: :Journal of Alzheimer's disease : JAD 2010
Xiaojuan Wang Anfeng Xing Changlei Xu Qing Cai Hong Liu Liang Li

Cerebrovascular hypoperfusion occurs prior to the clinical symptoms of Alzheimer's disease (AD) and represents the most accurate indicator predicting whether an individual develops AD at a future time. To study how cerebrovascular hypoperfusion contributes to AD, we induced cerebrovascular hypoperfusion by bilateral carotid occlusion surgery in adult rats and investigated its impacts on spatial...

Journal: :Neurology 2010
W T Hu Z Wang V M-Y Lee J Q Trojanowski J A Detre M Grossman

OBJECTIVE We examined the utility of distinguishing between patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD) using quantitative cerebral blood flow (CBF) imaging with arterial spin labeled (ASL) perfusion MRI. METHODS Forty-two patients with FTLD and 18 patients with AD, defined by autopsy or CSF-derived biomarkers for AD, and 23 matched controls were imaged w...

2014
Rajani Sebastian Mara G. Schein Cameron Davis Yessenia Gomez Melissa Newhart Kenichi Oishi Argye E. Hillis

Although aphasia and hemispatial neglect are classically labeled as cortical deficits, language deficits or hemispatial neglect following lesions to subcortical regions have been reported in many studies. However, whether or not aphasia and hemispatial neglect can be caused by subcortical lesions alone has been a matter of controversy. It has been previously shown that most cases of aphasia or ...

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