Thyrotoxic periodic paralysis is a unique disorder that causes episodic proximal lower extremity muscle weakness in patient who already has hyperthyroid state and not treated for the underlying disease state. The affected population mostly includes Asian origin specifically male gender (vs most thyroid affects women gender). Precipitating factors include addition to are strenuous exertion, high...

Abstract. This case of ascending paralysis, following an episode diarrhea, was initially misinterpreted as Guillain-Barré syndrome. The prominent hypokalemia led to the search for other differential diagnoses, interpreted a rare periodic hypokalemic which usually occurs in Asians after intake large amounts starch foods, such Spaghetti, or rest heavy exercise. In this case, reason with associate...

Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like pr...

We report a case of flaccid weakness in a 40 year old male farmer who presented to us with fever and bodyache. The patient had leptospirosis with a non- oliguric renal failure and flaccid weakness secondary to hypokalemia which improved following potassium correction and conservative measures.

OBJECTIVES To identify a clinically reliable index of thyrotoxic periodic paralysis (TPP), a life-threatening emergency with unique and effective therapies. DESIGN Diagnostic study. SETTING University teaching hospital. PATIENTS Fifty-three consecutive patients with hypokalemic paralysis during a 3-yr period and 30 thyrotoxic patients without paralysis as the thyrotoxic control group. I...

Periodic paralysis is a muscle disorder that belongs to the family of diseases called channelopathies, manifested by episodes of painless muscle weakness. Periodic paralysis is classified as hypokalemic when episodes occur in association with low potassium levels. Most cases are hereditary. Acquired cases have been described in association with hyperthyroidism. Diagnosis is made on clinical and...

Familial hypokalemic periodic paralysis is an autosomal-dominant channelopathy characterized by episodic muscle weakness with hypokalemia. The respiratory and cardiac muscles typically remain unaffected, but we report an atypical case of a family with hypokalemic periodic paralysis in which the affected members presented with frequent respiratory insufficiency during severe attacks. Molecular a...