Methyl (2), ethyl (3), propyl (4), butyl (5), allyl (6), benzyl (7), o-, m-, p-xylyl (8-10), and alpha-phenylethyl (11) derivatives of arabinofuranosyluracil (1) were synthesized and their pharmacological effects in mice were examined by using hypnotic activity and synergism with pentobarbital as indices for the CNS depressant effects. At a dose of 2.0 micromol/mouse by intracerebroventricular ...

GABA(A) receptors have been implicated in mediating several acute effects of ethanol including anxiolysis, ataxia, sedation/hypnosis, and anticonvulsant activity. Ethanol sensitivity of neurons has been associated with expression of alpha1 subunit-containing receptors. The objective of this study was to determine the contribution of alpha1 subunit containing receptors to ethanol responses in co...

ASSESSMENT OF HYPNOTIZABILITY ....................................................... 386 Alternatives ........................................................................................ 386 The Classic Suggestion Izffect .................................................................. 387 Hypnotic Susceptibility vs Hypnotic Depth ................................................... 388 C...

OBJECTIVES The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L. citriodora leave extracts and verbascoside were evaluated in mice. MATERIALS AND METHODS Animals were divided into 11 groups of six mice each. Group I received normal saline, Group II received D...

The hangover effects of 768 mg chlormethiazole, an hypnotic with a half-life of approximately 4 hr, were compared with those of placebo in a double-blind cross-over study in 8 young subjects. Ten hours after dosing there were no differences between the preparations in the subjects' psychomotor performance, EEG sleep scores, or visual analogue ratings. Thus, an hypnotic which is rapidly removed ...

A number of brain regions are associated with the subjective experience of pain. This study adds to our understanding of the neural mechanisms involved in pain by considering the relation between cortical oscillations in response to pain, with and without hypnosis and hypnotic analgesia, and the subjective experience of pain. Thirty-three subjects' neural responses (EEG) were measured during th...

Cold Control 2 Short Abstract We argue for the theoretical possibility of unconscious executive control using the Higher Order Thought (HOT) theory of Rosenthal (2002). Then we elaborate the cold control theory of hypnosis, according to which hypnotic response involves executive control without conscious intentions. Cold control theory allows an account of why some hypnotic tasks are more diffi...

INTRODUCTION The neurobiological basis of non-organic movement impairments is still unknown. As conversion disorder and hypnotic states share many characteristics, we applied an experimental design established in conversion disorder to investigate hypnotic paralysis. METHODS Movement imitation and observation were investigated by functional magnetic resonance imaging (fMRI) in 19 healthy subj...