IT IS generally recognized that some congenital malformations may be caused by an abnormal environment surrounding the mother in pregnancy. Many experiments have been reported concerning the teratogenesis due to various hypovitaminoses, but there are relatively few reports on teratogenesis resulting from the administration of a large quantity of vitamin. Among the latter, the best known are mal...

Prolonged hypervitaminosis D can result in calcium deposition in the soft tissues (especially the kidneys and heart), changes in the central nervous system & in severe cases, death. Patients and clinicians considering supplementation above currently recommended levels should be made aware of the possible toxicities of treatment with vitamin D, and baseline calcium and parathyroid hormone and vi...

Breitman, T. R., Selonick. S. E. & Collins, S. J. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 2936-2940 Dawson, M. I., Hobbs, P. D., Derdzinski, K., Chan, R. L.-S., Gruber, J., Chao, W., Smith, S., Thies, R. W. & Schiff, L. J. (1984) J . Med. Chem. 27, 15161531 Frickel, F. (1984) in The Retinoih (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), vol. I , pp. 7-145 Academic Press, Orlando, FL F...