AIM Whole exome sequencing (WES) is a recently developed method for discovering rare mutations associated with hereditary disorders. However, the feasibility and utilization of this method in identifying familial hypertriglyceridemia is not well known. The purpose of the study was to identify the genetic locus that causes hypertriglyceridemia and assess its prevalence in Taiwanese subjects with...

The hypertriglyceridemia of diabetes can be classified into mild to moderate (triglycerides between 150-499 mg/dL) and severe hypertriglyceridemia (triglycerides > or =500 mg/dL). As in any other individuals with hypertriglyceridemia, secondary causes need to be excluded. The management of severe hypertriglyceridemia (chylomicronemia syndrome) includes aggressive reduction of triglycerides with...

OBJECTIVE The aim was to develop clinical practice guidelines on hypertriglyceridemia. PARTICIPANTS The Task Force included a chair selected by The Endocrine Society Clinical Guidelines Subcommittee (CGS), five additional experts in the field, and a methodologist. The authors received no corporate funding or remuneration. CONSENSUS PROCESS Consensus was guided by systematic reviews of evide...

BACKGROUND Data regarding the prevalence of hypertriglyceridemia in the Russian population are lacking, despite triglyceride (TG)-mediated pathways being causal in cardiovascular disease. The prevalence of mixed dyslipidemia and severe hypertriglyceridemia in the Russian population (PROMETHEUS) was undertaken to address this gap. METHODS This was an observational, cross-sectional retrospectiv...

BACKGROUND Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis. METHODS We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects mo...

Hypertriglyceridemia is defined as an abnormal concentration of triglycerides in blood and is a commonly encountered lipid abnormality frequently associated with other lipid and metabolic derangements. Prolonged hypertriglyceridemia may produce neuropathological and abnormal metabolic changes particularly in peripheral sensory nerves. In the present study, we evaluated the role of several prote...

rising obesity incidence and its complications have lead to change of our view about cardio-metabolic risk factors and need of reassessment of these complications in childhood age. the aim of current study was to evaluate prevalence of obesity and related cardio-metabolic risk factors of children. this was a cross-sectional study in a representative sample of 12 years old children in rasht, the...