BACKGROUND Adverse drug reactions and adverse drug events (ADEs) are major public health issues. Many different prospective tools for the automated detection of ADEs in hospital databases have been developed and evaluated. The objective of the present study was to evaluate an automated method for the retrospective detection of ADEs with hyperkalaemia during inpatient stays. METHODS We used a ...

BACKGROUND The renal effects of cyclooxygenase-2 (COX-2) inhibitors have been incompletely elucidated, and acute renal failure (ARF) due to COX-2 inhibitors has been reported. METHODS In order to determine the causes of ARF and hyperkalaemia in five patients during COX-2 inhibitor therapy, we carefully analysed case studies of consecutive in-patients or out-patients referred to our Renal Divi...

AIMS To evaluate efficacy and safety of RLY5016 (a non-absorbed, orally administered, potassium [K+]-binding polymer) on serum K+ levels in patients with chronic heart failure (HF) receiving standard therapy and spironolactone. METHODS AND RESULTS One hundred and five patients with HF and a history of hyperkalaemia resulting in discontinuation of a renin-angiotensin-aldosterone system inhibit...

BACKGROUND Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients. Aldosterone excess is a risk factor for progression of kidney disease. Hyperkalaemia is a concern with the use of mineralocorticoid receptor antagonists. We aimed to determine whether ...

BACKGROUND Peptide receptor radionuclide therapy (PRRT) is routinely used for advanced or metastasized neuroendocrine tumours (NET). To prevent nephrotoxicity, positively charged amino acids (AA) are co-infused. The aim of this study was to correlate the risk for therapy-related hyperkalaemia with the total amount of AA infused. METHODS Twenty-two patients undergoing PRRT with standard activi...

Ureteral diversion in which the ureter is implanted into either the sigmoid colon or a short loop of ileum is associated with multiple metabolic complications [1,2]. Ureterosigmoidostomy commonly leads to metabolic acidosis due to the presence of colonic anion exchange pumps that reabsorb luminal chloride as bicarbonate is secreted across the sigmoid colon. In such cases, reabsorption of urinar...

Abstract Background/Introduction The renin-angiotensin-aldosterone system inhibitors (RAASI) are one of the keystones medical treatment in chronic cardiovascular disorders and have shown improvements clinical outcomes many trials. Hyperkalaemia is a well-defined non-desirable effect RAASI that occasionally forces to interrupt these medications. That enforced discontinuation or down-titration du...