نتایج جستجو برای: hyperinsulinemia

تعداد نتایج: 3911  

Journal: :Hypertension 1998
C Cardillo C M Kilcoyne S S Nambi R O Cannon M J Quon J A Panza

Insulin-mediated vasodilation has been proposed as an important determinant of whole-body insulin-stimulated glucose disposal. However, it is not clear whether the vasodilator effect of insulin results from a direct action of the hormone or whether alternative mechanisms are involved. To better characterize the mechanism of insulin-mediated vasorelaxation, we compared forearm blood flow (FBF) r...

Journal: :Journal of the American College of Cardiology 2003

Journal: :BMC Neurology 2021

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity. Methods We aimed determine the risk association of hyperinsulinemia in NMOSD patients seropositive AQP4-IgG and serum levels interleukin (IL)-6 IL-17A compared control group. Serum metabolic (Insul...

Journal: :Hypertension 1990
A P Rocchini C Moorehead S DeRemer T L Goodfriend D L Ball

To determine whether hyperinsulinemia alters angiotensin II-mediated aldosterone secretion, the increase in plasma aldosterone after intravenous angiotensin II (5, 10, and 20 ng/kg/min for 15 minutes each) was measured before and after euglycemic hyperinsulinemia in seven chronically instrumented dogs. In a random sequence on 4 successive days, dogs received either 0, 2, 4, or 8 milliunits/kg/m...

Journal: :American journal of physiology. Endocrinology and metabolism 2004
Jun Gao Lorraine Ghibaudi Joyce J Hwa

Central administration of neuropeptide Y (NPY) stimulates hyperphagia and hyperinsulinemia. Recent evidence has suggested that the Y1 and Y5 receptor subtypes may both mediate NPY-stimulated feeding. The present study attempts to further characterize the role of central NPY receptor subtypes involved in hyperinsulinemia. NPY and peptide analogs of NPY that selectively activated the NPY Y1 or Y5...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Michaela Siklova-Vitkova Jan Polak Eva Klimcakova Jindra Vrzalova Jindra Hejnova Michaela Kovacikova Zuzana Kovacova Magda Bajzova Lenka Rossmeislova Zuzana Hnevkovska Dominique Langin Vladimir Stich

Type 2 diabetes and obesity are associated with an enhanced release of a number of adipocytokines. Hyperinsulinemia, frequently present in type 2 diabetes and obesity, might be one of the drivers of the enhanced production of adipocytokines. The aim of this study was to investigate the interstitial levels of cytokines in subcutaneous adipose tissue (SCAT) in response to hyperinsulinemia and the...

Journal: :Current Obesity Reports 2017

Journal: :Diabetes 2007
Michael Krebs Barbara Brunmair Attila Brehm Michaela Artwohl Julia Szendroedi Peter Nowotny Erich Roth Clemens Fürnsinn Miriam Promintzer Christian Anderwald Martin Bischof Michael Roden

The nutrient-sensitive kinase mammalian target of rapamycin (mTOR) and its downstream target S6 kinase (S6K) are involved in amino acid-induced insulin resistance. Whether the mTOR/S6K pathway directly modulates glucose metabolism in humans is unknown. We studied 11 healthy men (29 years old, BMI 23 kg/m(2)) twice in random order after oral administration of 6 mg rapamycin, a specific mTOR inhi...

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