The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced ...

The pharmacological approach to the treatment of depression includes a long-term employment of antidepressants, either in the form of monotherapy or as a combination of several antidepressants with various mechanisms of action. Hypericum perforatum L. (St. John's wort) is the only natural antidepressant. Several constituents of the extract, such as hypericin and hyperforin, seem to be important...

OBJECTIVE To evaluate the antihyperglycemic activity of ethyl acetate extract of Hypericum perforatum (H. perforatum) in streptozotocin (STZ)-induced diabetic rats. METHODS Acute toxicity and oral glucose tolerance test were performed in normal rats. Male albino rats were rendered diabetic by STZ (40 mg/kg, intraperitoneally). H. perforatum ethyl acetate extract was orally administered to dia...

Gastric ulcer is a serious condition that results from the wearing/tearing of stomach mucosa. A physiological equilibrium maintained between mucosal defense and aggressive factors. In this study, effectiveness medicinal plants (Hypericum perforatum) in management gastric was compared to omeprazole, well-known drug for ulcer. This study involved numerous groups male rats comprising following: fi...

Parkinson's disease is characterized by a depletion of dopamine (DA) neurons in the nigrostriatal pathway. Stereotaxic injections of 6-hydroxydopamine (6-OHDA), a selective neurotoxin, into either the medial forebrain bundle or the substantia nigra result in a massive DA denervation of the nigrostriatal pathway. Following unilateral nigrostriatal DA depletion, hemiparkinsonian animals develop a...

Unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway produce side-biased motor impairments that reflect the motor deficits seen in Parkinson's disease (PD). This toxin-induced model in the rat has been used widely, to evaluate possible therapeutic strategies, but has not been well established in mice. With the advancements in mouse stem cell research we believe the require...

introduction: animal models of parkinson’s disease (pd) with partial damage of nigrostriatal dopaminergic system are very suitable for development of treatment strategies. although drug-induced rotational behavior has been conventionally used for analysis of lesioned animals, but bcause of the development of sensitization, it is necessary to invent a pure behavioral test that can evaluate such ...

Since ancient times, the essential oils (EOs) of many aromatic plants have been used as bioactive ingredients in drug, food and cosmetic formulations all over the world. Significant biological properties have also been attributed to Hypericum EOs. Hypericum is a genus of about 450 species in the Guttiferae family, formerly often treated separately in their own Hypericaceae family. Despite the l...

The dried aerial parts of Hypericum perforatum, gathered during the flowering period or shortly before, are used medicinally. The generic name of the herb derives from the Greek meaning to ‘overcome an apparition’ and in earlier times homes would have a plant hanging over the door to ward off evil spirits. This species of hypericum (H. perforatum) is referred to as perforate St John’s wort due ...

OBJECTIVES To compare the efficacy and tolerability of Hypericum perforatum (St John's wort extract) with imipramine in patients with mild to moderate depression. DESIGN Randomised, multicentre, double blind, parallel group trial. SETTING 40 outpatient clinics in Germany. PARTICIPANTS 324 outpatients with mild to moderate depression. INTERVENTION 75 mg imipramine twice daily or 250 mg h...