Development of a safe and effective method for gene delivery to hepatocytes is a critical step toward gene therapy for liver diseases. Here, we assessed the parameters for gene delivery to the livers of large animals (pigs, 40-65 kg) using an image-guided hydrodynamics-based procedure that involves image-guided catheter insertion into the lobular hepatic vein and hydrodynamic injection of repor...

A non-linear model-aided PD approach for implementing heading control algorithms in the 6000 m depth rated Remotely Operated Vehicle (ROSUB 6000) has been developed by National Institute of Ocean Technology, India is presented in this paper. ROSUB 6000 is developed for carrying out gas hydrate surveys, poly-metallic nodule exploration, deep water interventions, bathymetric surveys and salvage o...

The effects of hydrodynamic and thermal slip boundary conditions on the double-diffusive free convective flow of a nanofluid along a semi-infinite flat solid vertical plate are investigated numerically. It is assumed that free stream is moving. The governing boundary layer equations are non-dimensionalized and transformed into a system of nonlinear, coupled similarity equations. The effects of ...