Hydatidiform moles are the most common type of gestational trophoblastic neoplasia. Hyperproliferative vesicular trophoblasts and imperfect fetal development abnormal pregnancies, recurrent hydatidiform rare. Mutations in NLRP7 responsible for mole. Genetic heterogeneity has been demonstrated patients with mutation. This study presents our case gravida 11, parity 0, histopathologically diagnose...

Hydatidiform moles are abnormal conceptions characterised by atypical hyperplastic trophoblasts and hydropic villi. Their incidence is approximately 1 in 1000 pregnancies. The recurrence risk of hydatidiform mole is approximately 1 in 60 in a subsequent pregnancy and 1 in 6.5 in the third pregnancy. In cases with recurrence, the majority of moles are of the same type as that in the preceding pr...

Background Gestational trophoblastic disease is a group of benign and malignant entities, where the hydatidiform mole is the most common, and can be divided into complete hydatidiform mole and partial hydatidiform mole. However, the histological criteria are still questionable and also, histologic evaluation alone is prone to great interobserver variability. In this way, inmunohistochemical ana...

OBJECTIVE This study was undertaken to determine whether the expressions of 3 proliferation markers (Ki-67, proliferating cell nuclear antigen, and silver-staining nucleolar organizer regions) and of p53 tumor protein could differentiate spontaneous abortions from gestational trophoblastic diseases and also discriminate among gestational trophoblastic disease subgroups. STUDY DESIGN Twenty-tw...

This study investigated the expression and methylation profiles of SOX2, a stem cell-related transcription factor, in placentas and gestational trophoblastic disease. The methylation status of SOX2 promoter region in 55 hydatidiform moles, 4 choriocarcinoma, 23 first trimester, and 15 term placentas was evaluated by methylation-specific polymerase chain reaction. The methylated allele was found...

Hydatidiform mole (H. mole), a gestational trophoblastic disease, is common in the Philippines. In general, differentiation between complete hydatidiform and partial based on morphologic evaluation via routine H&E. The problem lies lack of standard criteria overlapping features. p57kip2 immunohistochemical stain inexpensive, locally available, could provide reliable results differentiating ...

BACKGROUND Differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. OBJECTIVE We analyzed the nuclear DNA content of various types of hydropic placentas by flowcytometry. MATERIALS AND METHODS DNA ploidy analysis was performed ...

OBJECTIVE To evacuate whether short-tandem-repeat (STR) DNA genotyping is effective for diagnostic measure to precisely classify hydatidiform moles. METHODS 150 cases were selected based on histologic features that were previously diagnosed or suspected molar pregnancy. All sections were stained with hematoxylin as a quality control method, and guided the microscopic dissection. DNA was extra...

background: differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management. objective: we analyzed the nuclear dna content of various types of hydropic placentas by flowcytometry. materials and methods: dna ploidy analysis was performed i...