نتایج جستجو برای: humanized

تعداد نتایج: 6443  

Journal: :Journal of virology 2012
Paul W Denton Rikke Olesen Shailesh K Choudhary Nancy M Archin Angela Wahl Michael D Swanson Morgan Chateau Tomonori Nochi John F Krisko Rae Ann Spagnuolo David M Margolis J Victor Garcia

Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4+ T cells that can be induced ex vivo to produce HIV. We observed that the levels of infected resting hu...

Journal: :The Journal of Experimental Medicine 1998
Margaret A. Holmes Timothy N. Buss Jefferson Foote

The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of the antigen combining site in the complex is nearly identical to that of the complexed form of the parent mouse antibody, D1.3. In contrast, the combining sites of the unliganded mouse and humanized antilysozymes show moderat...

Journal: :The Journal of infectious diseases 2013
Edward Seung Andrew M Tager

Humanized mice historically have not been good models of human humoral immunity induced by either infection or immunization. However, newer versions of humanized mice generated in severely immunodeficient mice with a targeted disruption of the IL2Rγc gene have recently been reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutralizing activities. Her...

Journal: :Journal of immunology 1998
X Y He Z Xu J Melrose A Mullowney M Vasquez C Queen V Vexler C Klingbeil M S Co E L Berg

E- and P-selectin (CD62E and CD62P) are cell adhesion molecules that mediate leukocyte-endothelial cell and leukocyte-platelet interactions and are involved in leukocyte recruitment during inflammation. We previously developed a murine mAb, EP-5C7 (or mEP-5C7), that binds and blocks both E- and P-selectin. When used in humans, murine mAbs have short circulating half-lives and generally induce p...

Journal: :Journal of immunology 2012
Qingfeng Chen Fang He Jimmy Kwang Jerry K Y Chan Jianzhu Chen

Engraftment of human hematopoietic stem cells into immunodeficient mice that lack T cells, B cells, and NK cells results in reconstitution of human blood lineage cells, especially B cells, in the recipient mice. However, these humanized mice do not make any significant level of IgG Ab in response to Ag stimulation. In this study, we show that in humanized mice, B cells are immature, and there i...

Journal: :The Journal of pharmacology and experimental therapeutics 2015
Dan Xu Manhong Wu Sachiko Nishimura Toshihiko Nishimura Sara A Michie Ming Zheng Zicheng Yang Alexander John Yates Jeffrey S Day Kathleen M Hillgren Saori Takedai Takeda Yuan Guan Yingying Guo Gary Peltz

Due to the substantial interspecies differences in drug metabolism and disposition, drug-induced liver injury (DILI) in humans is often not predicted by studies performed in animal species. For example, a drug (bosentan) used to treat pulmonary artery hypertension caused unexpected cholestatic liver toxicity in humans, which was not predicted by preclinical toxicology studies in multiple animal...

Journal: :JCI insight 2016
Chen Chen Woo-Yang Kim Peng Jiang

The creation of a humanized chimeric mouse nervous system permits the study of human neural development and disease pathogenesis using human cells in vivo. Humanized glial chimeric mice with the brain and spinal cord being colonized by human glial cells have been successfully generated. However, generation of humanized chimeric mouse brains repopulated by human neurons to possess a high degree ...

2017
José R. F. de Almeida Karla L. Santiago Gilberto H. Kaihami Andrea Q. Maranhão Marcelo de Macedo Brígido Sandro R. de Almeida

Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody w...

Journal: :The Journal of general virology 2014
Bradford K Berges Anne Tanner

The human herpesviruses (HHVs) are remarkably successful human pathogens, with some members of the family successfully establishing infection in the vast majority of humans worldwide. Although many HHV infections result in asymptomatic infection or mild disease, there are rare cases of severe disease and death found with nearly every HHV. Many of the pathogenic mechanisms of these viruses are p...

Journal: :Protein engineering 2000
C Caldas V P Coelho D J Rigden G Neschich A M Moro M M Brígido

The 6.7 murine monoclonal antibody (mAb) recognizes the human CD18 antigen and is therefore of interest as an anti-inflammatory agent. The 6.7 heavy variable chain (VH) was humanized using the closest human germline sequence as the template on to which to graft the murine complementary determining regions (CDRs). Two versions were proposed, one in which the residue proline 45 of the murine form...

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