Peptidy produkované mitochondriemi (mitochondrial-derived peptides, MDPs) jsou kódovány mitochon- driální DNA. Mezi MDP patří humanin, ribosomální ribonukleová kyselina typu c (ribosomal ribonucleic acid type c, MOTS-c) a malé humanin-like peptidy 1-6 (SHLP1-6). Ve stresových situacích podporují aktivitu mitochondrií napomáhají přežití buněk; kromě toho ovlivňují metabol...

Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery over a decade ago, a role for HN has been reported in many biological processes such as apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. HN and its potent analogs have been shown to have beneficial effects ...

BACKGROUND/AIM The excessive apoptosis of intestinal epithelial cells (IECs) partly accounts for the development of colonic inflammation and eventually results in ulcerative colitis (UC). Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. The present study aimed to investigate the effects of glysin v...

Humanin peptides (including HN, HNG and other mutants) were reported previously that antagonize neurotoxicity caused by various familial Alzheimer's disease (FAD) genes and Abeta derivatives. Herein, we describe the aggregation dynamics and the representative morphological characteristics of Abeta(1-40) after different time of addition humanin peptides, which revealed that (a) the interactions ...