background: mesenchymal stem cells (mscs) can be expanded and differentiated into many mature cell types including smooth muscle cells (smcs). in addition to growth factor, cyclic stretch contributes to differentiation of stem cells. mechanical stimuli are critical to morphological changes, development, regeneration, differentiation and pathology of mesenchymal tissues. the aim of this study is...

Introduction Based on previous researches, dental pulp stem cells (DPSCs) are easily accessible with limited morbidity after collection. Their embryonic origin, from neural crests, explains their multipotency. DPSCs are primarily derived from the pulp tissues of the teeth.Objective: This study was undertaken to isolate, culture, and characterize two different third molar and first premolar hum...

stem cell therapy is a powerful technique for the treatment of a number of diseases. stem cells are derived from different tissue sources, the most important of which are the bone marrow (bm), umbilical cord (uc) blood and liver. human uc mesenchymal stem cells (huc-mscs) are multipotent, non-hematopoietic stem cells that have the ability to self-renew and differentiate into other cells and tis...

objective: evaluating the effects of p-benzoquinone and hydroquinone on the runx2 expression and osteoblastic differentiation of human marrow derived mesenchymal stem cells (mscs). materials and methods: bone marrow mscs obtained by cultivating marrow mononuclear cells, were exposed to 10μm of either p-benzoquinone or hydroquinone. following chemical treatment, runx2 gene expression was assess...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...

in this present study, we examined the differentiation potential of human bone marrow derived mesenchymal stem cells (hbmscs) into hepatocytes on a three-dimentional (3d) nanofibrous scaffold formed by poly (ε-caprolactone) (pcl), collagen and polyethersulfone (pes). the nanofiber was prepared by the electrospining technique. hbmscs were isolated using combining gradient density centrifugation ...

this study discusses the effect of complexes of chitosan grafted polyethylenimine(ch-pei) with plasmid dna on viability of mesenchymal stem cells(mscs) derived from human marrow. ch-pei/pdna nanoparticles were synthesized through the complex coacervation method using pires plasmid containing green fluorescent protein (gfp) gene. to confirm the complexation, samples were run through an agarose g...

background: in recent years, adipose tissue, due to the stem cells contained within, has found a new special place in laboratory and clinical applications. these adipose‑derived stem cells (adscs) have the same characteristics of bone marrow mesenchymal stem cells (bmscs). although bone marrow (bm) is not easily accessible and its procurements may be painful, most patients possess excess fat wh...

objective(s): electrospun nanofibrous mats of poly(lactic acid) (pla) and nanohydroxyapatite (nano-ha) were prepared and proliferation and differentiation of mesenchymal stem cells on the prepared nanofibers were investigated in this study. materials and methods: pla/nano-ha nanofibers were prepared by electrospinning. the effects of process parameters, such as nano-ha concentration, distance, ...