the object of this cross sectional study was to determine the hcv subtype 3a envelope protein binding affinity with human leukocyte antigen. envelope 1 (e1) protein is one of the structural proteins responsible for entering the cells through the receptors. the binding affinity of e1 protein epitopes to the selected human leukocyte antigen (hla) class i alleles was investigated using the compute...

the human leukocyte antigen-b27 is one of the class i molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (as) . the strength of the disease association with b27 varies markedly among racial and ethnic populations. it is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distributi...

The non-classical human leukocyte antigen (HLA) class Ib genes, HLA-E, -G and -F, are located on chromosome 6 in the human major histocompatibility complex (MHC). HLA class Ib antigens resemble the HLA class Ia antigens in many ways, but several major differences have been described. This review will, in particular, discuss HLA-G and its role in human reproduction and in the human MHC. HLA-G se...

Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in ex...

Human leukocyte antigen (HLA) genes have been associated with susceptibility and protection against a number of cancers. Here we used an immunogenetic epidemiological approach to evaluate the overall influence 127 HLA Class I II alleles on 30 types cancer. We found preponderance protective (negatively correlated cancer prevalences), especially for I. Of cancers investigated, 13 were mostly effe...

Human leukocyte antigen-G molecules (HLA-G) have been suggested to play a role in immune evasion and progression of different malignancies by their tolerogenic activity, through interaction with inhibitory receptors on surface cells.The aim is evaluate the s HLA-G serum level prognosis therapeutic responses TKIs CML patients.Serum soluble was measured for total 61 adult patients CML, who were r...

the human leukocyte antigen (hla)-g molecule is expressed in cytotrophoblast cells, adult thymic epithelial cells, erythroblasts, pancreatic islets and mesenchymal stem  cells. although, hla-g expression in allotransplanted patients is correlated with a better allograft acceptance, it is associated with an advanced grade of the tumor in cancer. in addition to the role on the immune system, hla-...

introduction: human leukocyte antigen (hla) genes are the most polymorphic loci in the human genome. they predict the outcome of transplantation by detecting self from non-self antigens. the best use of hla typing is to find a hla-match donor for bmt candidate patients. evidence suggests that matching unrelated donors and recipients for hla-a, -b and -drb1 loci is a prediction for an improved o...