OBJECTIVE Leukocyte-associated immunoglobulin-like receptor-1 is an inhibitory receptor primarily expressed by immune cells. This study was undertaken to define the role of this molecule in osteoclast differentiation and rheumatoid arthritis. METHODS In vitro osteoclast assays were performed to characterize the role of Leukocyte-associated immunoglobulin-like receptor-1 in murine and human os...

the link between il-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. at the present study, we address the role of b cell derived il-13 in the ige and other immunoglobulin development. antisense oligo for human il-13 m-rna was used to study ige down regulation. human b-lymphocytes were purified by positive selecti...

Human immunoglobulin is an effective treatment for Guillain-Barré syndrome, although the mechanism of action is not understood. We have investigated the effect of human immunoglobulin in an animal model of Guillain-Barré syndrome, namely experimental autoimmune neuritis (EAN), induced in Lewis rats by immunization with bovine spinal root myelin. Human immunoglobulin administered intraperitoneal...

conclusions based on the findings of the present study, the frequency of toxoplasma infection is high in the studied population, although it is fairly close to the findings of reports from the other areas of iran. results in total, 1910 (29.87%) out of 6393 subjects were found to be infected with toxoplasma gondii. in terms of the seropositivity, 1871 (32.42%) out of 5770 and 128 (2.14%) out of...

Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils light chains produced clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting antibody, may improve outcomes for this disease.

Human immune serum globulin (HISG) therapy is the mainstay of treatment for patients with antibody immunodeficiency. Treatment with ‘y-globulin allows many of these patients to remain symptomfree for prolonged periods. Three types of human immunoglobulin are available for therapeutic use: (1) regular HISG for intramuscular (IM) use, derived from a panel of normal donors, therefore containing a ...

Hybrid antibodies possessing one binding site for the toxic lectin ricin and a companion site directed against human immunoglobulin were constructed in vitro. This bifunctional reagent specifically attached to human lymphocyte surface immunoglobulin determinants and, thus situated, could simultaneously capture ricin molecules or its toxic A chain. Attachment of these components to the cell was ...