نتایج جستجو برای: human epidermal growth factor receptor 2 her 2
تعداد نتایج: 5073461 فیلتر نتایج به سال:
Advances in Therapy for Hormone Receptor (HR)-Positive, Human Epidermal Growth Factor 2 (HER2)-Negative Advanced Breast Cancer Patients Who Have Experienced Progression After Treatment with CDK4/6 Inhibitors
Human epidermal growth factor receptor-2 (HER-2)/neu (ErbB2), a member of the epidermal growth factor family of receptors, is overexpressed in 20-30% of breast cancers. It is an attractive target for receptor-directed antitumor therapy using mAbs. Unlike other epidermal growth factor receptor family members, HER-2/neu does not bind a high-affinity ligand, but rather functions as the preferred d...
This study aimed to evaluate correlations between lymphovascular invasion (LVI) and the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), Ki-67, CK5/6, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, BCL11A and P53 in invasive breast cancer and to identify predictors of LVI based on...
زمینه و هدف: تزاید آنکوژن her-2/neu (human epidermal growth factor receptor/ neuroglioblastoma) بر روی پیشرفت، درمان و پیش آگاهی سرطان سینه موثر است. بررسی دقیق وضعیت her-2/neu بافت تومور، برای اداره بیماری و انتخاب صحیح بیماران پاسخگو به داروی جدید trastuzumab مهم می باشد. این مطالعه با هدف بررسی وضعیت ژن her-2/neu در نمونه های سرطان سینه توسط روش pcr تمایزی و تطابق موجود بین این روش با تست ای...
More on treatment de-escalation, biomarkers of response in human epidermal growth factor receptor 2 (HER2)-positive breast cancer: long-term outcomes and translational research findings the PREDIX HER2 trial
Members of the human epidermal growth factor receptor (HER) family—epidermal growth factor receptor (EGFR, HER1), HER2, HER3, and HER4—are transmembrane tyrosine kinase receptors that are important mediators of cell growth, development, and survival. Activation of the HER tyrosine kinases triggers intracellular signaling pathways, including the MAPK and PI3K-Akt pathways (Olayioye et al., 2000)...
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