Peroxovanadiums (pVs) are potent protein tyrosine phosphatase (PTP) inhibitors with insulin-mimetic properties in vivo and in vitro. We have established the existence of an insulin receptor kinase (IRK)-associated PTP whose inhibition by pVs correlates closely with IRK tyrosine phosphorylation, activation, and downstream signaling. pVs have also been shown to activate various tyrosine kinases (...

BACKGROUND Although HIV testing and counseling (HTC) uptake has increased dramatically in Africa, facility-based services are unlikely to ever meet ongoing need to the full. A major constraint in scaling up community and home-based HTC services is the unacceptability of receiving HTC from a provider known personally to prospective clients. We investigated the potential of supervised oral HIV se...

Home telecare (HTC), including remote monitoring and interactive video, is increasingly seen as a promising avenue for the timely provision of nursing interventions from a distance to patients at home. While empirical evidence are published regarding satisfaction, costs, suitable patient-populations and clinical outcomes, only three articles outlined the challenges that must be anticipated and ...

High-throughput computing (HTC) uses computer clusters to solve advanced computational problems, with the goal of accomplishing high-throughput over relatively long periods of time. In genomic selection, for example, a set of markers covering the entire genome is used to train a model based on known data, and the resulting model is used to predict the genetic merit of selection candidates. Soph...

We describe the characterization of a spontaneously transformed chicken monocytic cell line that developed as a single colony of cells in a heterophil culture that was inadvertently left in the incubator over a period of 25 days. These cells, hitherto named HTC, grow efficiently at both 37 or 41 degrees C in culture medium containing either 5% FBS or 2% chicken serum. The HTC cells are acid pho...

We show that, consistently, there is an ultrafilter F on ω such that if N n = (P l n ∪ Q l n, P l n, Q l n, R l n) (for l = 1, 2, n < ω), P l n ∪ Qn ⊆ ω, and Q

Consistent with the Couples HIV Testing and Counseling Guidelines recently released by the World Health Organization, we assert that the prevention impact of HTC will hinge on whether both members of HIV-discordant dyads receive HTC and whether they share their HIV status with each other. However, a better understanding of the prevention impact of other awareness possibilities is needed. We int...

In liver, the 470-residue bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyses the synthesis and degradation of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. In rat hepatoma (HTC) cells, this enzyme has kinetic, antigenic, and regulatory properties, such as insensitivity to cyclic AMP-dependent protein kinase and lack of associated ...

In a model liver cell line, recovery from swelling is mediated by a sensitive autocrine pathway involving conductive release of ATP, P2 receptor stimulation, and opening of membrane Cl- channels (Wang, Y., Roman, R. M., Lidofsky, S. D., and Fitz, J. G. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12020-12025). However, the mechanisms coupling changes in cell volume to ATP release are not known. B...

Cast aluminum alloys are usually subject to solution treatment, quenching, and aging hardening for improved mechanical properties. Cooling rate during quenching plays an important role in residual stress, distortion, and mechanical property distributions in the resultant cast aluminum components. As the cooling rates of work pieces heavily depend on the interfacial heat transfer coefficient (HT...