objectives: regarding the implication of viruses particularly herpes in pemphigus vulgaris, we sought to assess and compare the level of immunoglobulin g (igg) antibodies against herpes simplex virus types 1 and 2 (hsv1 and hsv2), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with pemphigus vulgaris and healthy people.     materials and methods: in this cross-sectional study, 2...

In human recurrent cutaneous herpes simplex, there is a sequential infiltrate of CD4 and then CD8 lymphocytes into lesions. CD4 lymphocytes are the major producers of the key cytokine IFN-gamma in lesions. They recognize mainly structural proteins and especially glycoproteins D and B (gD and gB) when restimulated in vitro. Recent human vaccine trials using recombinant gD showed partial protecti...

Background: Pemphigus is a group of autoimmune blistering skin diseases that is related to auto antibodies against desmoglein 1 and 3. Many reports have shown that HSV1, HSV2, VZV, EBV, CMV, HHV8, and HIV are triggering agents for the activation and exacerbation of pemphigus. In this study, we decided to evaluate the frequen...

deficiency and allergies. Methods: Clinical and laboratory tests were conducted on 579 potentially healthy people (172 women and 407 men, between 25 and 30 years), performed twice: in a diagnosis and after 6 to 12 months. Lymphocytes and NK cells from peripheral blood were assessed using cytometry. G, A, M immunoglobulin concentrations were determined by the turbidimetry. IgE concentration was ...

OBJECTIVES Evidence on the association between herpes simplex virus (HSV) and excessive adiposity, such as obesity (body mass index ≥30 kg/m2) and abdominal obesity (waist circumference (WC) >102 or 88 cm), has been inconsistent. We sought to examine whether age-period-cohort (APC) effects could explain for the observed heterogeneities. DESIGN Population-based cross-sectional study. PARTICI...

deficiency and allergies. Methods: Clinical and laboratory tests were conducted on 579 potentially healthy people (172 women and 407 men, between 25 and 30 years), performed twice: in a diagnosis and after 6 to 12 months. Lymphocytes and NK cells from peripheral blood were assessed using cytometry. G, A, M immunoglobulin concentrations were determined by the turbidimetry. IgE concentration was ...

BACKGROUND We previously demonstrated that the risk of coronary artery disease (CAD) increased in relation to the number of pathogens (the "pathogen burden") in a cross-sectional study. In the present prospective study with a different patient cohort, we evaluated the effect of pathogen burden on the risk of myocardial infarction (MI) or death among CAD patients. METHODS AND RESULTS IgG antib...

Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses including herpes simplex types 1 (HSV-1) and 2 (HSV2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In cell cultures, acyclovir has the highest antiviral activity against HSV-1, followed in decreasing order of potency against HSV-2, ...

Histiocytic necrotizing lymphadenitis (HNL) or Kikuchi's disease is a distinctive, self-limited disorder characterized by necrotizing cervical lymphadenopathy in young individuals. HNL is more prevalent among Asians and is a relatively common disorder among Koreans. A preceding fever, lymphopenia, and occasional skin rashes suggest a viral etiology and there have been sporadic reports of viral ...

Autophagy is an intracellular degradation system by which cytoplasmic materials are enclosed by an autophagosome and delivered to a lysosome/vacuole. Atg18 plays a critical role in autophagosome formation as a complex with Atg2 and phosphatidylinositol 3-phosphate (PtdIns(3)P). However, little is known about the structure of Atg18 and its recognition mode of Atg2 or PtdIns(3)P. Here, we report ...