This study was done to assess bioequivalence between test and reference formulations of escitalopram oxalate 20 mg in healthy Indian male subjects. This single-dose, randomized, open-label, 2-period crossover study was carried out in 12 Healthy Indian Male volunteers aged 18 to 55 years under fasting conditions with a wash out of 14 days.  The subjects were randomly assigned to receive the test...

Hypotension is frequently reported during hemodialysis. This study aimed to examine the effect of the intermittent pneumatic circulator on blood pressure during hemodialysis. Sixteen subjects with chronic hemodialysis were recruited. Each subject randomly received two test conditions on separate days, hemodialysis with and without the circulator. The circulator was applied to the subject on low...

Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V1 receptors or the central cholinergic system play roles in these cardiov...

Fifteen broiler chickens (COBB 400) of 42 days of age weighing 1.8 to 2.0 kg were equally divided into 3 groups, each consisting of 5 birds. Hepatopathy was induced by oral administration of paracetamol while nephropathy was induced by intravenous administration of uranyl nitrate. Kinetic study was investigated in healthy, hepatopathic and nephropathic birds following single oral administration...

purpose the present study was designed to evaluate the effects of aerobic and strength training on cardiac variables such as blood pressure, heart rate (hr), and metabolic parameters like cholesterol, high density lipoprotein (hdl), triglycerides and anthropometric parameters of obese women of punjab. methods this study was performed as an experimental study, in which subjects were randomly sel...

ôbjective: to investigate the pharmacokinetics (pk) and pk- pharmacodynamic (pd) relationship of methadone in a cohort of outpatients undergoing methadone maintenance treatment (mmt). methods: sixty male patients undergoing mmt with a mean ±sd methadone daily dosage of 58 ± 34 mg were enrolled in this study. â 5-ml blood sample was collected before the daily intake of methadone. âs a pd measure...