نتایج جستجو برای: hpv16 e6

تعداد نتایج: 6321  

2017
Yan Hu Jin-Ze Wu Hua Zhu Sheng-Hui Zhang Yan-Ying Zhu Yi-Yao Wu Ci-Xia Shuai

Potential correlation of human papillomavirus (HPV) 16 E6 variants and human leukocyte antigen (HLA) class II polymorphisms has been suggested in patients with cervical cancer, so far little information is available about the possible interaction between E6 variants and HLA class II variability during the obviously accelerated progression to cervical cancer in young women. In this study, we aim...

Journal: :Journal of medical virology 2007
Yuping Wu Benrong Liu Wenzhi Lin Yunping Xu Longyu Li Yanling Zhang Shangwu Chen Anlong Xu

Infection with human papillomavirus type 16 (HPV16) confers a high risk for the development of cervical cancer. Variants of this virus may interact differentially with host genetic factors, possibly affecting the disease pathogenesis. This study was designed to investigate the association between HPV16 E6 variants and human leukocyte antigen (HLA) polymorphism within a Chinese population. Perip...

2016
Li Sun Shubin Xu Lei Liang Liang Zhao Lei Zhang

Cervical carcinoma is a multifactorial malignant tumor and diagnosis is therefore crucial. The aim of the present study was to examine the value of E6 oncoprotein, in human papillomavirus type 16 (HPV16), in the diagnosis of early stage cervical carcinoma and precancerous lesions. Receiver operating characteristic curve was used to analyze accuracy of diagnosis. A total of 124 patients infected...

Journal: :Journal of virology 1997
Y Shino H Shirasawa T Kinoshita B Simizu

Although human papillomavirus type 16 (HPV16) E6 protein has a transcription-modulatory activity for a wide variety of viral promoters, a cellular target for this activity of E6 has not yet been identified. In this study, using differential hybridization, we identified a mouse fibronectin (FN) gene as a putative cellular target whose expression is up-regulated by E6. Chloramphenicol acetyltrans...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016
Lu-Lu Yu Le-Ni Kang Fang-Hui Zhao Xiao-Qin Lei Yu Qin Ze-Ni Wu Hong Wang Wen Chen You-Lin Qiao

BACKGROUND An association between high-risk human papillomavirus (HR-HPV) oncoprotein expression and viral persistence has been suggested by the outcome of etiology studies, but there are no epidemiologic studies evaluating that link. METHODS We performed a 3-year prospective study in which 2,498 Chinese women ages 25 to 65 years were screened by six screening tests, including the Onco E6: Ce...

Journal: :Journal of virology 2012
Iris Cornet Tarik Gheit Silvia Franceschi Jerome Vignat Robert D Burk Bakary S Sylla Massimo Tommasino Gary M Clifford

Naturally occurring genetic variants of human papillomavirus type 16 (HPV16) are common and have previously been classified into 4 major lineages; European-Asian (EAS), including the sublineages European (EUR) and Asian (As), African 1 (AFR1), African 2 (AFR2), and North-American/Asian-American (NA/AA). We aimed to improve the classification of HPV16 variant lineages by using a large resource o...

Journal: :Journal of clinical microbiology 2008
Maëlle Saunier Sylvain Monnier-Benoit Frédéric Mauny Véronique Dalstein Jenny Briolat Didier Riethmuller Bernadette Kantelip Elisabeth Schwarz Christiane Mougin Jean-Luc Prétet

Integration of human papillomavirus (HPV) DNA into the host cell genome is a frequent event in cervical carcinogenesis, even though this phenomenon does not seem to be mandatory for cervical cancer development. Our objective was to describe the load and physical state of HPV type 16 (HPV16) DNA in a series of cervical samples representative of the natural history of cervical cancer. We used a c...

2018
Wanxue Wang Zhenni Yue Zhengping Tian Yiran Xie Jiamiao Zhang Yuanping She Bing Yang Yuan Ye Yihua Yang

The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown. This study explored abnormal expression of Yin Yang 1 (YY1) in cervical cancer and its correlation with the expression of E-cadherin and human papillomavirus (HPV) 16 E6. YY1, E-cadherin and HPV16 E6 ...

Journal: :Acta biochimica Polonica 2017
Slawa Szostek Barbara Zawilinska Malgorzata Klimek Magdalena Kosz-Vnenchak

The aim of this study was to analyse the correlation between HPV16 E6 variants and the physical status of viral genome (integrated, mixed, episomal) among patients with cervical cancer (n=40) and low-grade squamous intraepithelial lesions - LSIL (n=40). The study was performed on 80 HPV16 positive samples. HPV16 E6 variants were identified using PCR and DNA sequencing. Nucleotide sequences of E...

Journal: :Journal of virology 2004
Ilaria Malanchi Rosita Accardi Frank Diehl Anouk Smet Elliot Androphy Jörg Hoheisel Massimo Tommasino

We show that E6 proteins from benign human papillomavirus type 1 (HPV1) and oncogenic HPV16 have the ability to alter the regulation of the G(1)/S transition of the cell cycle in primary human fibroblasts. Overexpression of both viral proteins induces cellular proliferation, retinoblastoma (pRb) phosphorylation, and accumulation of products of genes that are negatively regulated by pRb, such as...

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