In present study mucoadhesive buccal tablet of simvastatin was prepared. Solubility of Simvastatin was enhanced by complexing Simvastatin with β-CD in 1:2 molar concentrations. Six different formulations of tablets of Simvastatin containing the polymers in various combinations were prepared by direct compression method and characterized for swelling studies, % matrix erosion, surface pH, mucoad...

The Montelukast pulsatile delivery system was created with the goal of delivering drug to colon for successful treatment nocturnal asthma. microspheres were sealed within insoluble hard gelatin capsule body an erodible hydrogel plug create a time delayed capsule. Emulsion solvent evaporation used make microspheres. Based on dissolving tests, optimised microsphere formulations designed. entire d...

Zolmitriptan is the antimigraine agent widely used for treatment of migraine. It shows half-life 2.5 – 3 h which indicate frequent dosing to achieve proper pharmacological action drug. Gastro Retentive Drug Delivery System (GRDDS) a common approach decrease frequency and increase patient compliance, delivery drug through such an floating tablet formulation will meet requirement. This system sho...

Mucoadhesive vaginal tablets of tenofovir disoproxil fumarate (TDF) have been formulated using hydroxypropyl methylcellulose (HPMC K100) as the matrix forming retarding agent with various mucoadhesive polymers such as carbopol 934, 940, chitosan and sodium carboxymethylcellulose and evaluated. Wet granulation method was employed to make the tablets. Drug-excipient compatibility, precompression ...

The purpose of the study was to prepare and evaluate clarithromycin (CLA) floating tablets using experimental mixture design for treatment of Helicobacter pylori provided by prolonged gastric residence time and controlled plasma level. Ten different formulations were generated based on different molecular weight of hypromellose (HPMC K100, K4M, K15M) by using simplex lattice design (a sub-class...

Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially efficacious for initiation of sleep, and theref...

Escherichia coli K100 produces an antigenic determinant similar to, or identical with, the capsular antigen of Haemophilus influenzae type b. Studies of the effects of heat on the immunogenicity, erythrocyte-modifying capacity, and antigenicity of this cross-reacting antigen (CRA) revealed the following findings. Immunization of rabbits with viable or formaldehyde-killed suspensions of E. coli ...

The current research aims to formulate and evaluated Cinnamaldehyde transdermal patches treat diabetes. A good penetration enhancer Oleic Acid, would improve drug delivery from various polymer-based patches. Transdermal of the matrix type were made by solvent casting techniques using polymer PVP K30, HPMC K100, solvent. All prepared formulations tested for folding endurance, weight variation, t...

Introduction: Ketorolac tromethamine is a potent injectable non-steroidal antiinflammatory drug (NSAID). Ketorolac provides successful analgesia after intrathecal or epidural injection. It is frequently used to manage post-operative pain, cancer pain, and arthritis either intrathecally, or intramuscular. However, its long term administration could induce renal toxicity and/or gastro-intestinal ...

The study on the effect of polymer concentration in vitro drug release profile revealed that there is a change parameters (t50, t80, and MDT) with concentration. Fraction HPMC K4M, K 100 M, Ethyl Cellulose were required to be 15, 10, 7 mg respectively for designing optimized batch F7. rate Colchicine decreased proportionally an increase ethyl K100 M. Also high amount K4M leads less initial sust...