Protein-protein interactions, a key to almost any biological process, are mediated by molecular mechanisms that are not entirely clear. The study of these mechanisms often focuses on all residues at protein-protein interfaces. However, only a small subset of all interface residues is actually essential for recognition or binding. Commonly referred to as "hotspots," these essential residues are ...

Among mammals, genetic recombination occurs at highly delimited sites known as recombination hotspots. They are typically 1-2 kb long and vary as much as a 1,000-fold or more in recombination activity. Although much is known about the molecular details of the recombination process itself, the factors determining the location and relative activity of hotspots are poorly understood. To further ou...

This paper is to explore new ways to better understand urban system emphasizing on detection and analysis of urban area hotspots through cell phone traffic data. Firstly, according to the characteristics of GSM network, Voronoi cellular network is introduced to determine the service area of the base station. Then two visualization methods are discussed through analyzing the distribution of cell...

MOTIVATION The detection of genomic regions unusually rich in a given pattern is an important undertaking in the analysis of next-generation sequencing data. Recent studies of chromosomal translocations in activated B lymphocytes have identified regions that are frequently translocated to c-myc oncogene. A quantitative method for the identification of translocation hotspots was crucial to this ...

Quantitative trait loci (QTL) hotspots (genomic locations affecting many traits) are a common feature in genetical genomics studies and are biologically interesting since they may harbor critical regulators. Therefore, statistical procedures to assess the significance of hotspots are of key importance. One approach, randomly allocating observed QTL across the genomic locations separately by tra...

this paper presents the results obtained from the life cycle assessment (lca) of the productionof sicilian artichokes (cynara scolymus) with the aim of reducing impacts, interpreting the results, suggesting possible improvements and enriching the sustainability knowledge already existing in the agro food field. artichokes represent one of the excellent italian agricultural products even if stil...

Motivation: The detection of genomic regions unusually rich in a given pattern is an important undertaking in the analysis of next generation sequencing data. Recent studies of chromosomal translocations in activated B lymphocytes have identified regions that are frequently translocated to c-myc oncogene. A quantitative method for the identification of translocation hotspots was crucial to this...

The mechanisms driving the nucleation, spread, and dissipation of crime hotspots are poorly understood. As a consequence, the ability of law enforcement agencies to use mapped crime patterns to design crime prevention strategies is severely hampered. We also lack robust expectations about how different policing interventions should impact crime. Here we present a mathematical framework based on...

The spatial heterogeneity of malaria suggests that interventions may be targeted for maximum impact. It is unclear to what extent different metrics lead to consistent delineation of hotspot boundaries. Using data from a large community-based malaria survey in the western Kenyan highlands, we assessed the agreement between a model-based geostatistical (MBG) approach to detect hotspots using Plas...

QTL hotspots (genomic locations affecting many traits) are a common feature in genetical genomics studies, and are biologically interesting since they may harbor critical regulators. Therefore, statistical procedures to assess the significance of hotspots are of key importance. One approach, randomly allocating observed QTLs across the genomic locations separately by trait, implicitly assumes a...