A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD i...

Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

to find the effect of atriplex canescens on soil chemical properties, two adjacent areas, each with and area of 1 ha, were selected in hossein abad hapeshloo shahryar. in one area it was planted atriplex canescens in 2003 while the later one without atriplex canescens was considered as control area. to sample soil, random- systematic method was used along 3 transects with a length of 100 m. in ...

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.

extended abstract 1. introduction the quality of life can be considered as an operational tool to measure the overall health and welfare. in general, the concept quality of life is affected by various factors constituting the foundation of the life dynamics. since the concept quality of urban life is multidimensional and complex, it could be used in urban planning when an appropriate and reliab...

BACKGROUND Since Pars Abad district had been known as a focus of visceral leishmaniasis (VL) in Ardabil Province but the prevalence of the disease in nomadic tribes has not been determined, thus, this study was conducted. METHODS This descriptive cross-sectional study was conducted on children up to 12yr old of nomadic tribes from Pars Abad County, Ardabil Province, Iran in 2015. For each ind...

In the acute setting, the majority of patients affected by uncomplicated acute type B aortic dissection (ABAD) can be managed with medical therapy. In these patients, inhospital outcome is generally acceptable, with mortality rates of 1-10% (1,2). However, long-term outcomes in this group is less positive, with a mortality rates reported as 2025% within 3 years. Predictors of long-term complica...

The purpose of this study was identifying rangeland development andrestoration operations targets. This study was conducted in Hossein Abad Bazoft basinwith 7162 ha area, located in south east of Farsan County, Chaharmahal and BakhtiariProvince, Iran. The basin has various land uses including rangeland, forest, irrigated farmand garden, dry farm, residential area and rock mass. In this study, d...

We show that there may be a Milliken-Taylor ultrafilter with infinitely many near coherence classes of ultrafilters in its projection to ω, answering a question by López-Abad. We show that k-coloured Milliken-Taylor ultrafilters have at least k + 1 near coherence classes of ultrafilters in its projection to ω. We show that the Mathias forcing with a Milliken-Taylor ultrafilter destroys all Mill...