We have previously reported that thyroid hormone decreases the concentration of its nuclear-bound receptor and stimulates growth hormone synthesis in cultured GH, cells, a rat pituitary cell line (Samuels, H. H., Stanley, F., and Shapiro, L. E. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 38773881). In that study, we could not determine whether the initiating event in thyroid hormone action resul...

Retinoic acid receptor-related orphan receptors (ROR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [11, 3]) have yet to be assigned a definitive endogenous ligand, although RORα may synthesized with ‘captured’ agonist such cholesterol [68, 67].

background: breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. the purpose of this study was to determine the relationship between estrogen and progesterone receptors with her-2, ki67, p53, and clinicopathologica...

Hormone receptor status assessment is necessary for selecting cancer patients who might potentially benefit from endocrine therapy. To determine whether hormone receptor status changes during tumor progression, we retrospectively examined 107 high-grade serous ovarian cancer (HGSC) patients with paired primary and recurrent tumor specimens. Hormone receptor expression discordance rates between ...

introduction: the etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. it seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. the aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (er) and progesterone receptor (pr...

The nuclear receptor (NR) superfamily is comprised of transcription factors that are ligand‑activated in their majority and play a pivotal role biological functions essential for life, such as metabolism homeostasis. Following activation, they undertake the regulation target genes with help co‑regulator proteins, rendering them very promising pharmacological targets. In total, 59 NRs have been ...

In this research study, the effect of baclofen (GABAB receptor agonist) on mean concentration of growth hormone, thyroxine, and triiodothyronine was examined. For this purpose, twelve Holstein Cows were divided into four groups. Then, each cow received daily injection of 25, 50, 75, and l00 mg/kg of baclofen for a period of four days. Blood samples were daily collected at one time point for eig...