Actinomycin D has been tested on mouse tu mors, with varying degrees of success, as an anti-neoplastic agent. Dramatic inhibition of some ascites (mouse) tumors has been reported by Sugiura (14) and Gregory et al. (6). Reilly (11) and Sugiura (14) are in agreement that actino-mycin D has slight antineoplastic activity against S-180, and Farber (3) demonstrated antitumor activity against the mal...

Angioimmunoblastic T-cell lymphoma (AITL) is a frequent subtype of peripheral T – cell lymphoma (PTCL) characterized by generalized lymphadenopathy, hepatosplenomegaly, and frequent B symptoms. Extranodal manifestations are quite common in this subtype of Non Hodgkins Lymphoma which is characterized by frequent skin involvement. However, the extranodal disease should be evaluated thoroughly and...

The role of rituximab has expanded beyond the treatment of non-Hodgkins lymphoma, to include successful management of rheumatoid arthritis, systemic lupus erythematosus, anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis and primary glomerulonephritis. Decrease incidence of side-effects or toxicity, coupled with clinical effectiveness, suggests that B-cell depleting agents may ...

Gougerot sjogren syndrome is a mild, slowly progressive autoimmune disease associated with low morbidity and mortality, characterized primarily by organ-specific manifestations systemic manifestations. Indeed, these complications, feared during the evolution, have been known reported for many years. This risk of non-hodgkin lymphoma is, moreover, notably greater primary than any other pathology...

AIM To determine the pattern and causes of lymph node enlargement of cervical region in Ibadan, Nigeria. MATERIALS AND METHODS A 10-year (2003-2012) retrospective study was conducted on all head and neck lymph node biopsies received at the Department of Pathology, University College Hospital, Ibadan, Nigeria. RESULTS A total of 101 lymph node biopsies of cervical region were received within...

Mediastinal masses in children comprise a heterogeneous group of malignant and benign neoplasms. The majority of malignant tumors of mediastinum are Hodgkins and non-Hodgkins lymphomas, germ cell tumors, and neuroblastomas. Thymic tumors account for 1.5% of mediastinal masses in children [1]. Thymomas, thymic carcinoids, and thymic carcinomas constitute thymic epithelial neoplasms (TEN). Carcin...