Ethanol potentiates glycinergic synaptic transmission to hypoglossal motoneurons (HMs). This effect on glycinergic transmission changes with postnatal development in that juvenile HMs (P9-13) are more sensitive to ethanol than neonate HMs (P1-3). We have now extended our previous study to investigate ethanol modulation of synaptic GABA(A) receptors (GABA(A)Rs), because both GABA and glycine med...

Heterochromatin underpins gene repression, genome integrity, and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, conserved protein complexes effect heterochromatin formation via RNA interference-mediated recruitment of a histone H3 lysine 9 methyltransferase to cognate chromatin regions. To identify small molecules that inhibit heterochromatin formation, we performed an ...

The current Internet is facing serious scalability problems and the overloading of Internet Protocol (IP) addresses is regarded as an important reason. The Locator/ID Separation Protocol (LISP) is proposed as a network-based solution that separates IP addresses into Routing Locators (RLOCs) and Endpoint Identifiers (EIDs) to address the routing scalability problems. It is a critical challenge f...

Tissue engineering scaffolds with a micro- or nanoporous structure and able to deliver special drugs have already been confirmed to be effective in bone repair. In this paper, we first evaluated the biomineralization properties and drug release properties of a novel mesoporous silica-hydroxyapatite composite material (HMS-HA) which was used as drug vehicle and filler for polymer matrices. Biomi...

This paper develops a framework for regional scale flood modeling that integrates NEXRAD Level III rainfall, GIS, and a hydrological model (HEC-HMS/RAS). The San Antonio River Basin (about 4000 square miles, 10,000 km2) in Central Texas, USA, is the domain of the study because it is a region subject to frequent occurrences of severe flash flooding. A major flood in the summer of 2002 is chosen ...

estimation of parameters of a hydrologic model is undertaken using a procedure called “calibration” in order to obtain predictions as close as possible to observed values. this study aimed to use the particle swarm optimization (pso) algorithm for automatic calibration of the hec-hms hydrologic model, which includes a library of different event-based models for simulating the rainfall-runoff pr...

BACKGROUND The aim of this study was to develop and validate a reliable clinical prediction rule that could be employed to identify patients at higher likelihood of mortality among those with hematological malignancies (HMs) and bacterial bloodstream infections (BBSIs). METHODS AND FINDINGS We conducted a retrospective cohort study in nine Italian hematological units. The derivation cohort co...

arid and semi-arid regions of the world are confronted with limited water resources. a large part of iran is arid and semi-arid and rainfall in arid and semi-arid regions is typically meager, irregular and highly variable. this irregularity affects the hydrological cycle and water resources. investigating the hydrology of the arid and semi arid regions is essential to know this environment and ...

In this paper we propose a dynamic model selection technique based on hidden model sequences (HMS). HMS modelling assumes, that not only the actual state sequence is unknown, but also the model sequence given a particular sentence. This allows more than one model to be used for a particular phone in a certain context. The most appropriate model is determined locally rather than a priori globall...