BACKGROUND & AIMS Mucosal healing, determined by histologic analysis, is a potential therapeutic target for patients with ulcerative colitis (UC). However, the histologic features of tissue normalization, as an outcome of treatment, have not been well described. We examined the prevalence and predictive values of normalization of the colonic mucosa, based on histologic analysis (histologic norm...

Abstract Background In ulcerative colitis (UC), persistent histological activity is associated with higher rates of relapse and long-term complications, even when endoscopic remission achieved; therefore, healing a potentially important treatment target. Etrasimod an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 (S1P1,4,5) modulator for the moderately to se...

although the diagnostic category of atypical squamous cells of undetermined significance (ascus) has been known since 1988, its use and appropriate clinical follow up and management still remains controversial. this study was carried out to evaluate the diagnostic value of ascus, using cytohistologic correlation. a retrospective review of archival materials in our cytology laboratory files was ...

abstract: adequate processing of tissues before histologic slices is necessary for preparation of proper histologic sections in animal studies. fixation is one of the most important and early laboratory stages of tissue processing. amount of penetration time of fixator material, into deep layers and central portions of hard tissues, is important factor for prevention of cell lysis. the purpose ...

In human breast cancer, estrogen receptor (ER) status of the tumor has prognostic and therapeutic significance. However, facilities to study ER are not widely available to us. We postulated that if there is a correlation between histologic grade and ER status of invasive ductal carcinoma (IDC), it may help predict the ER status of the tumor. Of 8 4 cases of breast carcinoma referred to the ...