Label-free detection of the interaction between hexahistidine-tagged human κ-opioid receptor membrane protein and anti-His antibody is demonstrated in liquid by an optical microelectromechanical system utilizing electromagnetically actuated microresonators. Shift in resonance frequency due to accretion of mass on the sensitive surface of microresonators is monitored via an integrated optical re...

We evaluate the ability of hexahistidine (His6) tags on peptide and protein substrates to recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes, one that creates tyrosine-RNA nucleopeptides and another that phosphorylates tyrosine side chains, we find substantial improvements in yield, kobs, and Km for peptide substrates due to recruiting by His6/Cu(2+). Howeve...

T summer of 1949 was long and dry in Montana. On the afternoon of August 5th—the hottest day ever recorded in the state—a lightning fire was spotted in a remote area of pine forest. A parachute brigade of fifteen firefighters known as smoke jumpers was dispatched to put out the blaze; the man in charge was named Wag Dodge. When the jumpers left Missoula, in a C-47 cargo plane, they were told th...

Dr. Seyed Taghi Noorbakhsh died in a tragic car accident on Nov 15th 2018, while on an official mission in Golestan Province in Iran. There is a great emptiness left by Dr.Noorbakhsh’s passing. He will be missed by his colleagues andthousands of his patients whom he helped during his career.In addition to being a board member of Iranian Orthopedic Association (IOA), for consecutive terms & Chie...

We present a molecular theory to study the adsorption of different species within pH-sensitive hydrogel nanofilms. The theoretical framework allows for a molecular-level description of all the components of the system, and it explicitly accounts for the acid-base equilibrium. We concentrate on the adsorption of hexahistidine, one of the most widely used tags in bio-related systems, particularly...

This is my farewell editorial as editor of Methods of Information in Medicine, a journal of Schattauer Verlag [1]. After having had the pleasure and honour to work for this journal as editor for more than 14 years (cf. [2], p 495), it is now time for “transferring the helm” once again [3] and “passing on the fire” [4] to the next generation: the fire of serving to adequately communicate high-qu...

Field experiments with man-made fires in a forest were conducted to verify fire warning products from satellite remote sensing techniques and to select more effective channels for producing these products. Pine branches and trunks as well as other woods were burned at a designated place in a pine-dominated forest to simulate wild forest fires when a satellite was passing over the sky. Infrared ...