The amino acid requirements for the growth of Pasteurella pestis have been studied by a number of workers (Rao, 1939; Doudoroff, 1943; Herbert, 1949; Hills and Spurr, 1952; Rockenmacher et al., 1952; and Higuchi and Carlin, 1958). Very little is known, however, regarding the role of peptides in the nutrition of this organism. Peptides have been reported to be superior to free amino acids in the...

The real-time polymerase chain reaction (real-time PCR) is a recent modification to PCR (UNIT 10.2) that is rapidly changing the nature of how biomedical science research is conducted. It was first introduced in 1992 by Higuchi and coworkers and has seen a rapid increase in its use since (Higuchi et al., 1992, 1993). Real-time PCR allows precise quantification of specific nucleic acids in a com...

Our recent extended constrained-search theory @M. Higuchi and K. Higuchi, Phys. Rev. B 69, 035113 ~2004!# enables us to choose arbitrary quantities as the basic variables of density functional theory. In this paper, we apply it to several cases. In the case in which the occupation matrix of localized orbitals is chosen as a basic variable, we can obtain the single-particle equation which is equ...

Chondroitin sulfate and sodium alginate were incorporated in different ratios to prepare glutaraldehyde (GA) crosslinked microspheres by water-in-oil emulsion crosslinking method for delivery of 5-flurouracil (5-FU) to colon. Chemical interaction, surface morphology, thermal degradability, crystallinity evaluation, elemental analysis and drug release results were computed by using FTIR, SEM, DS...

This chapter provides an introduction to evolvable hardware. First, the basic idea of evolvable hardware is outlined. Because evolvable hardware involves the integration of programmable logic device and evolutionary computation, these are both explained briefly. Then, an overview of current research on evolvable hardware is presented. Finally, the chapter discusses some directions for future re...

Y. Bito, T. Shirai, S. Hirata, Y. Taniguchi, K. Hirata, Y. Otake, Y. Soutome, H. Ochi, T. Ebisu, Y. Kawai, M. Umeda, T. Higuchi, and C. Tanaka Central Research Laboratory, Hitachi, Ltd., Kokubunji-shi, Tokyo, Japan, Neurosurgery, Nantan General Hospital, Kyoto, Japan, Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan, Neurosurgery, Meiji University of Integrative Medic...

1. Amano T., Ushiyama K., Fujita G., Higuchi H., 2004. Alleviating grazing damage by white-fronted geese: an optimal foraging approach. J. Appl. Ecol. 41, 675–688, https://doi.org/10.1111/j.0021... CrossRef Google Scholar

Several musical genres have been demonstrated to encourage changes in cardiac autonomic modulation. So, we aimed to investigate the acute effects of auditory stimulation with heavy metal music by applying the Higuchi fractal dimension algorithm. The study was performed in 19 healthy women aged between 18 and 30 years old. HRV was analysed during two time phases: the 20-minute period without exp...

Kiyoshi Sanada, Motoyuki Iemitsu, Haruka Murakami, Izumi Tabata, Kenta Yamamoto, Yuko Gando, Katsuhiko Suzuki, Mitsuru Higuchi, and Motohiko Miyachi College of Sport and Health Science, Ritsumeikan University, Shiga; Consolidated Research Institute for Advanced Science and Medical Care, Waseda University; Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo; and Facu...