The PET-CT scanner, which overlays a high spatial resolution CT image on a relatively low resolution physiologic PET image, has greatly increased the efficacy of the PET imaging modality. With the resulting increase in the presence of PET imaging in the radiologic and medical physics communities, medical physicists can expect professional responsibilities in acceptance testing, quality assuranc...

Positron emission tomography (PET) is used in the clinic and in vivo small animal research to study molecular processes associated with diseases such as cancer, heart disease, and neurological disorders, and to guide the discovery and development of new treatments. This paper reviews current challenges of advancing PET technology and some of newly developed PET detectors and systems. The paper ...

Prostate cancer is one of the most common forms of cancer among men. Early diagnosis, correct staging, accurate detection of metastasis, and monitoring of the therapy are the key tasks that could greatly benefit from medical imaging. After a review of the main developments in the field of positron emission tomography (PET) tracers for prostate cancer, the impact of improved PET instrumentation ...

Genome-wide functional analyses require high-resolution genome assembly and annotation. We applied ChIA-PET to analyze gene regulatory networks, including 3D chromosome interactions, underlying thyroid hormone (TH) signaling in the frog Xenopus tropicalis. As the available versions of Xenopus tropicalis assembly and annotation lacked the resolution required for ChIA-PET we improve the genome as...

Introduction: An efficient method of tomographic imaging in nuclear medicine is positron emission tomography (PET). Compared to SPECT, PET has the advantages of higher levels of sensitivity, spatial resolution and more accurate quantification. However, high noise levels in the image limit its diagnostic utility. Noise removal in nuclear medicine is traditionally based on Fourier decomposition o...

Images from positron emission tomography (PET) provide metabolic information about the human body. They present, however, a spatial resolution that is limited by physical and instrumental factors often modeled by a blurring function. Since this function is typically unknown, blind deconvolution (BD) techniques are needed in order to produce a useful restored PET image. In this work, we propose ...

A method for partial volume correction of positron emission tomography (PET) images is proposed. The method is based on combining information from PET and high resolution anatomical images. Two different algorithms fast wavelet transform and à trous were implemented in order to decompose the PET and high resolution images. Results obtained using several simulated images show a significant parti...

This article discusses attenuation correction strategies in positron emission tomography/computed tomography (PET/CT) and 4-dimensional PET/CT imaging. Average CT scan derived from averaging the high temporal resolution CT images is effective in improving the registration of the CT and the PET images and quantification of the PET data. It underscores list-mode data acquisition in 4-dimensional ...