Liver is the primary organ for glucose metabolism. Apart from expressing the enzymes involved in glucose metabolism and regulation, liver possesses numerous enzymes involved in detoxification and toxicity enhancement (Phase I and Phase II). Also, most substances, upon entry into the body are primarily subjected to metabolism in the liver. Reports dealing with the effects of high glucose on live...

objective(s):the aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. materials and methods: twenty one wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. meanwhile, adropin was administrated intraperitonealy ...

High-glucose-induced cardiomyocyte injury is the major cause of diabetic cardiomyopathy, but its regulatory mechanisms are not fully understood. Here, we report that a circadian clock gene, brain and muscle Arnt-like 1 (Bmal1), increases autophagy in high-glucose-induced cardiomyocyte injury. We constructed a hyperglycemia model with cultured cardiomyocytes from neonatal rats. High-glucose-indu...

BACKGROUND Toxicity to glucose is not a normal state, however, it has been reported that after certain individuals ingest sugar, they produce excess tumor necrosis factor. CASE REPORT An other wise healthy 47 year old male developed a severe sensitivity to foods containing sugar over a 12 year period. After eating certain foods containing sugars he would develop angst, pain in his extremities...

background: high fasting plasma glucose (fpg) is one of the main leading risk factors of ischemic heart disease (ihd), stroke, and chronic kidney diseases (ckds). we estimated population attributable fraction (paf) and attributed death of these fatal outcomes of high fpg at national and subnational levels in 25–64 years old iranian adult. methods: we used national and subnational data of the no...

Background: Evaluation on the toxicity of two mainly contaminant heavy metals, cadmium (Cd) and lead (Pb) through the food chain was the aim of this study. Methods: A total number of 270 healthy common carp (4±1.14 g) in April, 2015 transported to the Khatam Alanbia University of Technology, Behbahan, Iran. Fishes were divided into three groups and transferred to the 20 L aquaria each...

diazinon is an organophosphate which is extensively used in trade and agriculture. due to its widespread application, its toxicity is common. several studies have shown that organophosphates are able to induce oxidative stress by generating free radicals and depletion of endogenous antioxidants. pomegranate seed oil (pso) possesses anti-inflammatory and antioxidant effects. in this study, the e...

Mitochondrial toxicity is increasingly being implicated as a contributing factor to many xenobiotic-induced organ toxicities, including skeletal muscle toxicity. This has necessitated the need for predictive in vitro models that are able to sensitively detect mitochondrial toxicity of chemical entities early in the research and development process. One such cell model involves substituting gala...

We have administered the glycolysis inhibitors 2-deoxy-D-glucose and 5-thio-D-glucose to C3H/HeJ mice bearing KHT or 16/C transplantable tumors to seek evidence for hypoxic cell toxicity in vivo. The drugs were given (a) with or without insulin, (b) as large single doses or as multiple hourly injections, and (c) alone or immediately after the tumors had received radiation to kill most of the ae...

In the Republic of Benin, several plants, including Zea mays Linn (Z. mays) are used for treatment diabetes without any scientific studies showing their effectiveness. The objective this study is to investigate effects Z. leaves’ extracts on hyperglycaemic rabbits using Oral Glucose Tolerance Test (OGTT), 2 g/kg (D) + glucose and hepatic liberation. Phytochemical screening revealed that plant l...