We describe the clinical and biochemical features of six men with male pseudohermaphroditism due to androgen resistance. Each of the subjects had male-gender behavior but incomplete virilization. The underlying defects in androgen metabolism were defined by studies of the 5a-reductase enzyme and the androgen receptor in fibroblasts cultured from biopsies of genital skin. Four of the six have 5a...

The dopamine hypothesis for the mode of action of antipsychotic drugs has been with us for some 30 years and has, by and large, withstood the test of time. It simply states that antipsychotic drugs owe their therapeutic effects to an ability to block central dopamine receptors. This has given us a working and testable explanation for the effects of these drugs and it has prompted the synthesis ...

High-dose chemotherapy in breast cancer is a subject of considerable controversy. Preliminary results from several randomized trials have shown that it is certainly not the breakthrough hoped for in the early 1990s. The available data are, however, compatible with a modest but potentially important effect on relapse-free survival in the adjuvant treatment of high-risk breast cancer. To prove su...

objective(s): the aim of this study was to determine whether high-dose radioactive iodine (na131i) outpatient treatment of patients with thyroid carcinoma is a pragmatically safe approach, particularly for the safety of caregivers. methods: a total of 79 patients completed the radiation-safety questionnaires prior to receiving high-dose radioactive iodine treatment. the questionnaire studied th...

background: dosimetry is a fundamental part of the radiation processing industry. aqueous inorganic dosimeters have been used for gamma radiation dosimetry such as standard ferrous sulfate dosimeter. the purpose of this study was to investigate the effect of gamma radiation on the diethyl fumarate def in dimethyl sulfoxide dmso solution and its possible use in chemical dosimetry. materials and ...

Objective(s): The aim of this study was to determine whether high-dose radioactive iodine (Na131I) outpatient treatment of patients with thyroid carcinoma is a pragmatically safe approach, particularly for the safety of caregivers. Methods: A total of 79 patients completed the radiation-safety questionnaires prior to receiving high-dose radioactive iodine treatment. The questionnaire studied th...

background: for effective treatment of organophosphate (op) poisoning, development of a standardized protocol with flexible dose regimen for atropine and pralidoxime is an essential step. in this study, we aimed to assess the protocol devised in our setting; bach mai hospital poison treatment center, for treatment of op poisoning that included a higher dose regimen of pralidoxime (2pam). method...

Introduction: Quality assurance is essential for obtaining the best achievable tumor control, avoiding unnecessary side effects, accuracy and safety during performing High Dose Rate (HDR) Brachytherapy (BT). Quality assurance is extremely important because HDR BT procedures are performed quickly, with high doses given in a short time period, with little opportunity for correcti...